7390-78-5_三酪氨酸、Tyr-Tyr-Tyr_H2N-Tyr-Tyr-Tyr-OH_H2N-YYY-OH_三肽_ 杭州专肽生物技术有限公司的多肽产品

三酪氨酸、Tyr-Tyr-Tyr
三酪氨酸 YYY 的苦味是由于其显着的疏水性。Narai-Kanayama 和 Aso 表明 Tyr-Tyr (G-3480) 和 Tyr-Tyr-Tyr 有效抑制兔肺血管紧张素 I 转换酶 (ACE)，其 IC₅₀ 值分别为 34 μM 和 51 μM。这两种酪氨酸肽表现出竞争性和非竞争性抑制的混合。

编号：153795

CAS号：7390-78-5

单字母：H2N-YYY-OH

编号:	153795
中文名称:	三酪氨酸、Tyr-Tyr-Tyr
中文同义词:	L-酪氨酰-L-酪氨酰-L-酪氨酸
英文名:	Tyr-Tyr-Tyr
英文同义词:	TripeptideYYY
CAS号:	7390-78-5
单字母:	H2N-YYY-OH
三字母:	H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Tyr L-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -Tyr L-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -Tyr L-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	3
分子式:	C₂₇H₂₉N₃O₇
平均分子量:	507.54
精确分子量:	507.2
等电点(PI):	-
pH=7.0时的净电荷数:	3.97
平均亲水性:	-3.4
疏水性值:	-0.9
外观与性状:	白色粉末状固体
沸点:	940.6±65.0°Cat760mmHg
消光系数:	4470
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
纯度:	95%、98%
盐体系:	可选TFA、HAc、HCl或其它
生成周期:	2-3周
储存条件:	负80℃至负20℃
标签:	三肽

MDL号:	MFCD00055745
参考文献（References）:	<ALLPEPTIDE>Anne Beilvert, et al. Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection. Chem Commun (Camb). 2011 May 21;47(19):5506-8.<ALLPEPTIDE>Asako Narai-Kanayama, et al. High level production of bioactive di- and tri-tyrosine peptides by protease-catalyzed reactions. J Biotechnol. 2010 Nov;150(3):343-7.
TPSA:	182.21
LogP :	1.2128
H_Acceptors:	7.0
H_Donors:	7.0
Rotatable_Bonds:	11.0
警示词:	Warning
危险申明:	H302-H315-H319-H335
警告申明:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
GHS编码:	GHS07
SMILES:	O=C([C@@H](N)CC1=CC=C(O)C=C1)N[C@H](C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=C(O)C=C3

The bitter taste of tri-tyrosine, YYY, is due to its marked hydrophobicity. Narai-Kanayama and Aso showed that Tyr-Tyr (G-3480) and Tyr-Tyr-Tyr efficiently inhibit angiotensin I-converting enzyme (ACE) from rabbit lung, their IC₅₀ values were 34 μM and 51 μM, respectively. These two tyrosine peptides exhibited a mix of competitive and noncompetitive inhibitions.

H-Tyr-Tyr-Tyr-OH is a synthetic compound that has been used to study the mechanism of lactoperoxidase. Lactoperoxidase is an enzyme that catalyzes the oxidation of thiocyanate to form hypothiocyanite, hydrogen peroxide, and a hydroxy group. The hydroxy group is formed by the reaction of two molecules of hydrogen peroxide with a molecule of thiocyanate. This reaction produces an oxygen atom, which then reacts with water to produce an acid. H-Tyr-Tyr-Tyr-OH has been shown to be a substrate for lactoperoxidase in horse serum and bovine serum. It has also been found to react with oxygen at neutral pH levels, forming a product that absorbs ultraviolet light at 280 nm.

三酪氨酸YYY的苦味是由于其显着的疏水性。Narai-Kanayama和Aso表明Tyr-Tyr(G-3480)和Tyr-Tyr-Tyr可有效抑制兔的血管紧张素I转换酶(ACE)肺，它们的IC50值为34μM

DOI	名称
10.1081/lpr-64956	Effect of tryptophan oligopeptides on the size distribution of POPC liposomes: a dynamic light scattering and turbidimetric study	下载
10.1016/j.jinorgbio.2006.07.009	Reduction of plastocyanin by tyrosine-containing oligopeptides	下载