LL-37, human 是一种由37 个氨基酸残基组成的两亲性组织蛋白酶衍生的抗菌肽，具有广泛的抗菌活性。
编号：125937
CAS号：154947-66-7
单字母：H2N-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH
| 编号: | 125937 |
| 中文名称: | 两亲性组织蛋白酶衍生的抗菌肽：LL-37 (Cathelicidin) |
| 英文名: | LL-37 (Cathelicidin) |
| 英文同义词: | LL37 |
| CAS号: | 154947-66-7 |
| 单字母: | H2N-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH |
| 三字母: | H2N N端氨基 -Leu亮氨酸 -Leu亮氨酸 -Gly甘氨酸 -Asp天冬氨酸 -Phe苯丙氨酸 -Phe苯丙氨酸 -Arg精氨酸 -Lys赖氨酸 -Ser丝氨酸 -Lys赖氨酸 -Glu谷氨酸 -Lys赖氨酸 -Ile异亮氨酸 -Gly甘氨酸 -Lys赖氨酸 -Glu谷氨酸 -Phe苯丙氨酸 -Lys赖氨酸 -Arg精氨酸 -Ile异亮氨酸 -Val缬氨酸 -Gln谷氨酰胺 -Arg精氨酸 -Ile异亮氨酸 -Lys赖氨酸 -Asp天冬氨酸 -Phe苯丙氨酸 -Leu亮氨酸 -Arg精氨酸 -Asn天冬酰胺 -Leu亮氨酸 -Val缬氨酸 -Pro脯氨酸 -Arg精氨酸 -Thr苏氨酸 -Glu谷氨酸 -Ser丝氨酸 -OHC端羧基 |
| 氨基酸个数: | 37 |
| 分子式: | C205H340N60O53 |
| 平均分子量: | 4493.26 |
| 精确分子量: | 4490.58 |
| 等电点(PI): | 11.7 |
| pH=7.0时的净电荷数: | 6.98 |
| 平均亲水性: | 0.67647058823529 |
| 疏水性值: | -0.72 |
| 消光系数: | - |
| 标签: | 未分类肽 |
LL-37, human 是一种由37 个氨基酸残基组成的两亲性组织蛋白酶衍生的抗菌肽，具有广泛的抗菌活性。它有助于保护角膜免受感染，对于伤口愈合有着良好的促进作用，同时对多种革兰氏阳性和革兰氏阴性病原体具有抗菌和抗生物膜活性。
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
LL-37是一种具有血管生成活性的抗菌肽。它对应于人组织蛋白酶抗菌蛋白hCAP18/LL-37的C末端序列（134-170），并通过蛋白水解过程从hCAP18/LL-37细胞外释放。hCAP18/LL-37是先天免疫系统的效应器，在白细胞和上皮细胞中表达，与炎症和损伤相关上调。可以证明hCAP18/LL-37在一系列乳腺癌中的过表达。LL-37被认为部分通过甲酰肽受体样1（FPRL1）刺激上皮细胞增殖，因为用百日咳毒素阻断受体会使LL-37的增殖作用降低约50%。
LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.bbamem.2006.03.030 | LL-37, the only human member of the cathelicidin family of antimicrobial peptides | 下载 |
| 10.1167/iovs.05-1649 | Multifunctional roles of human cathelicidin (LL-37) at the ocular surface | 下载 |
| 10.1371/journal.pone.0124706 | Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses | 下载 |
| 10.1371/journal.pone.0133454 | Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis | 下载 |
| 10.1172/JCI17545 | An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 | 下载 |
| 10.1002/ijc.20795 | Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells | 下载 |
| 10.1152/ajplung.00286.2004 | Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure | 下载 |
| 10_1002cplu_202200240 | Self-Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective | 下载 |
