PMX 53是一种有效的口服活性C5aR（CD88）拮抗剂和Mas相关基因2（MrgX2）激动剂。
编号：437533
CAS号：219639-75-5/551935-77-4/852629-88-0/852629-87-9/51
单字母：
| 编号: | 437533 |
| 中文名称: | PMX 53 acetate |
| 英文名: | PMX 53 acetate |
| CAS号: | 219639-75-5，freebase 551935-77-4，x-acetatesalt 852629-88-0，醋酸盐 852629-87-9，TFA盐 51，x-TFAsalt |
| 三字母: | Ac-FXPAWR.CH3CO2H (Modifications: X-2 = Orn, Ala-4 = D-Ala, Disulfide bridge between Orn2-Arg6) |
| 分子式: | C47H65N11O7.C2H4O2 |
| 平均分子量: | 956.14 |
| 标签: | 其它激动剂多肽(Agonist Peptide) |
PMX 53是一种有效的口服活性C5aR（CD88）拮抗剂和Mas相关基因2（MrgX2）激动剂。它刺激MrgX2介导的肥大细胞脱颗粒，抑制C5a诱导的中性粒细胞髓过氧化物酶释放和趋化性，抑制小鼠乳腺癌症模型中的肺转移，并减少小鼠动脉粥样硬化模型中的动脉粥样硬化病变。
PMX 53 is a potent and orally active C5aR(CD88) antagonist and Mas-related gene 2 (MrgX2) agonist. It stimulates MrgX2-mediated mast cell degranulation, inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis, inhibits lung metastasis in a mouse breast cancer model, and reduces atherosclerotic lesions in a mouse model of atherosclerosis.
