400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
An inhibitor of dipeptidyl aminopeptidase IV.
编号：138690
CAS号：90614-48-5
单字母：H2N-IPI-OH
| 编号: | 138690 |
| 中文名称: | 抑二肽素A、Diprotin A |
| 中文同义词: | 抑二肽素A;L-异亮氨酰-L-脯氨酰-L-异亮氨酸;Ile-Pro-Ile;H-Ile-Pro-Ile-OH;L-Isoleucyl-L-prolyl-L-isoleucine |
| 英文名: | Diprotin A |
| CAS号: | 90614-48-5 |
| 单字母: | H2N-IPI-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 3 |
| 分子式: | C17H31N3O4 |
| 平均分子量: | 341.45 |
| 精确分子量: | 341.23 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.8 |
| 疏水性值: | 2.47 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 三肽 |
| 溶解度: | Soluble in water |
An inhibitor of dipeptidyl aminopeptidase IV.
Diprotin A is a peptide that is involved in cell signaling and has been shown to interact with ion channels and receptors. It is an activator of the Fc receptor, which is responsible for the activation of immune cells. This peptide can also be used as a research tool to study protein interactions or as an antibody to study ligands or receptors. Diprotin A can be used in the pharmacological treatment of diseases such as cancer, inflammation, and pain.
Dpp-iv is a serine protease enzyme that is important for the production of vasoactive peptides and inflammatory mediators. It is involved in the regulation of heart function, blood pressure, and vascular tone. Inhibitors of Dpp-iv have been shown to be useful in the treatment of a variety of diseases including hypertension, coronary artery disease, myocardial infarction, and stroke. Diprotin A is a synthetic inhibitor that has been shown to prevent adenoviral vector-mediated heart damage in neonatal animals. This drug also inhibits the production of vasoactive peptides and inflammatory mediators by blocking Dpp-iv activity, preventing cardiac dysfunction following an infarction.
双肽素 A 是一种三肽抑制剂，用于研究蛋白酶特异性，特别是 X‑Pro 切割系统。其紧凑序列便于酶‑底物相互作用动力学评估。研究人员通过结合谱理解抑制模式。该分子支持机制酶学研究。
Diprotin A is a tripeptide inhibitor used to study protease specificity, particularly in X-Pro cleavage systems. Its compact sequence facilitates kinetic evaluation of enzyme-substrate interactions. Researchers analyze its binding profile to understand inhibitory patterns. The molecule supports mechanistic enzymology research.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.foodchem.2012.02.183 | Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran | 下载 |
| 10.1039/c4fo00983e | In vitro bioactive properties of intact and enzymatically hydrolysed whey protein: targeting the enteroinsular axis | 下载 |
| 10.1042/BJ20021643 | Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII | 下载 |
| 10.2337/diacare.26.3.837 | Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes | 下载 |
| 10.1128/AAC.49.3.1087-1092.2005 | Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium | 下载 |
| 10.1111/j.1742-4658.2005.04631.x | The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity | 下载 |
| 10.1016/j.neuint.2006.05.006 | The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats | 下载 |
| 10.1021/jm0606490 | Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach | 下载 |
| 10.1089/scd.2007.9997 | Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells | 下载 |
| 10.1016/j.peptides.2007.07.012 | Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats | 下载 |
| 10.33549/physiolres.931231 | Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines | 下载 |
| 10.1152/ajpendo.90233.2008 | Incretin and islet hormonal responses to fat and protein ingestion in healthy men | 下载 |
| 10.1007/s11064-008-9853-z | The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats | 下载 |
| 10.1016/j.exphem.2009.03.005 | Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A | 下载 |
| 10.1038/oby.2009.378 | Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats | 下载 |
| 10.1210/jc.2011-0266 | Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans | 下载 |
| 10.1016/j.biocel.2012.01.011 | Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity | 下载 |
| 10.1016/j.molmet.2013.11.010 | Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency | 下载 |
| 10.1210/jc.2014-3865 | Incretin effect after oral amino acid ingestion in humans | 下载 |
| 10.1186/s13098-015-0075-7 | Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice | 下载 |
| 10.7164/antibiotics.37.422 | Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria | 下载 |
| 10.1016/s0014-5793(98)00515-8 | Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens | 下载 |
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