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九聚精氨酸是最有效的蛋白质转导结构域之一,也是一种细胞穿透肽。阳性电荷序列。
编号:198599
CAS号:2283335-13-5/143413-47-2
单字母:H2N-RRRRRRRRR-OH
(Arg)9 TFA (Nona-L-arginine TFA)是可渗透细胞的多肽,在谷氨酸模型实验模型中保护神经的IC50值为0.78 μM。
(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
Nonaarginine是最有效的蛋白质转导结构域之一,也是一种细胞穿透肽。
Nonaarginine is one of the most efficient protein transduction domains and a cell-penetrating peptide.
(Arg)9 is an cell-penetrating peptide made up of 9 arginine residues capable of traversing plasma membranes. It has been shown that Arg9 destabilize and disrupt the phospholipid bilayer allowing flow of ions across the membrane. (Arg)9 peptide plays an important role in efficient cellular uptake. The guanidinium group is a critical structural determinant for tight and rapid interactions with cell membrane. The cationic guanidinium group can form electrostatic interactions with anionic cell membranes components such as phospholipids and sulphated proteoglycans. This interaction can trigger the activation of specific intracellular signalling and cell internalization via various pathways. (Arg)9 peptide is used to deliver a variety of functionally active cargos such as peptides, small interfering RNA, oligonucleotides, plasmid DNA and liposomes into mammalian cells and plant cells with high translocation efficiency. (Arg)9 peptide can also be used to form chemical linkages with the cargo and act as a carrier peptide.
| DOI | 名称 | |
|---|---|---|
| 10.1007/s10571-013-9999-3 | The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures | 下载 |
| 10.1038/jcbfm.2015.11 | Poly-arginine and arginine-rich peptides are neuroprotective in stroke models | 下载 |
| 10.1186/s12868-016-0253-z | Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model | 下载 |
| 10.1074/jbc.M209548200 | Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake | 下载 |
| 10.1002/cbic.200600209 | A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway | 下载 |





