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七精氨酸作为精氨酸低聚物,无论是单独的还是与治疗剂或大型生物聚合物偶联时,都已显示出易于穿过各种生物膜(例如脂质双层和上皮组织)。
编号:128769
CAS号:165893-48-1
单字母:H2N-RRRRRRR-OH
七精氨酸作为精氨酸低聚物,无论是单独的还是与治疗剂或大型生物聚合物偶联时,都已显示出易于穿过各种生物膜(例如脂质双层和上皮组织)。鸟嘌呤基团在转运中的重要性得到了以下观察结果的支持:精氨酸的短寡聚物进入细胞的速度远远快于赖氨酸、组氨酸、鸟氨酸或瓜氨酸的相应寡聚物。
Arginine oligomers as heptaarginine, either alone or when conjugated to therapeutic agents or large biopolymers, have been shown to cross readily a variety of biological membranes (e.g. lipid bilayers and epithelial tissue). The importance of the guanidinium group in transport was supported by the observation that short oligomers of arginine entered cells far more rapidly than the corresponding oligomers of either lysine, histidine, ornithine, or citrulline.
单独或与治疗剂或大型生物聚合物组合的H-Arg-Arg-Arg-Arg-Arg-OH已被证明可以容易地穿过各种生物膜(例如脂质双层和上皮组织)。鸟嘌呤基团在转运中的重要性得到了以下观察结果的支持:精氨酸的短寡聚物进入细胞的速度远远快于赖氨酸、组氨酸、鸟氨酸或瓜氨酸的相应寡聚物。
H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH, either alone or in combination with therapeutic agents or large biopolymers, has been shown to easily cross a variety of biofilms (e.g. lipid bilayers and epithelial tissue). The importance of the guanidinium group in transport is supported by the observation that short oligomers of arginine enter cells far more rapidly than the corresponding oligomers of either lysine, histidine, ornithine or citrulline.
| DOI | 名称 | |
|---|---|---|
| 10.1021/jm0105676 | Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake | 下载 |
| 10.1016/j.bbrep.2017.06.007 | Peptide translocation across MOMP, the major outer membrane channel from Campylobacter jejuni | 下载 |
| 10.1016/s0301-4622(01)00267-8 | Proteolysis of protein C in pooled normal plasma and purified protein C by activated protein C (APC) | 下载 |
| 10.3390/ijms23115993 | Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel | 下载 |
| 10.1155/2014/243185 | H-CRRETAWAC-OH, a lead structure for the development of radiotracer targeting integrin α5β1? | 下载 |





