400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 206400 |
| 中文名称: | Fmoc-D-异亮氨酸、Fmoc-DIle-OH |
| 中文同义词: | Fmoc-D-异亮氨酸 |
| 英文名: | Fmoc-D-Ile-OH |
| 英文同义词: | Fmoc-D-Isoleucine |
| CAS号: | 143688-83-9 |
| 单字母: | Fmoc-i-OH |
| 三字母: | Fmoc N端Fmoc保护，9-芴甲氧羰基（Fmoc）是伯胺和仲胺的保护基团。在固相肽合成（SPPS）中，它是氨基酸主链的常用保护基，因为它可以很容易地用哌啶去除，而不会干扰树脂和肽之间的酸不稳定连接体。 -DIleD型异亮氨酸 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 1 |
| 分子式: | C21H23O4N1 |
| 平均分子量: | 353.41 |
| 精确分子量: | 353.16 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.8 |
| 疏水性值: | 4.5 |
| 外观与性状: | 粉末状固体 |
| 沸点: | 559.8°Cat760mmHg |
| 熔点: | 143-145°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | Fmoc保护氨基酸 D型氨基酸 异亮氨酸类 |
| MDL号: | MFCD00080291 |
| 参考文献（References）: | <ALLPEPTIDE>Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.<ALLPEPTIDE>Binu Jacob, et al. The stereochemical effect of SMAP-29 and SMAP-18 on bacterial selectivity, membrane interaction and anti-inflammatory activity. Amino Acids. 2016 May;48(5):1241-51. |
| TPSA: | 75.63 |
| LogP : | 4.0244 |
| H_Acceptors: | 3.0 |
| H_Donors: | 2.0 |
| Rotatable_Bonds: | 6.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | CC[C@H]([C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)C(O)=O)C |
Fmoc-D-Ile-OH is a peptide that inhibits the activation of protein interactions. It is also used as a research tool to study the binding of ligands to receptors. Fmoc-D-Ile-OH has been shown to bind to ion channels, such as nicotinic acetylcholine receptor and voltage gated potassium channels. This inhibitor has also been shown to bind with high affinity to a receptor with unknown identity.
