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Orphanin FQ(1-11) 是孤儿蛋白 FQ 或 nociceptin (OFQ/N) 片段，是一种有效的 NOP (ORL-1; OP4) 受体激动剂，Ki 为 55 nM。Orphanin FQ(1-11) 对 μ，δ，κ1 和 κ3 受体没有亲和力 (Ki>1000 nM)。Orphanin FQ(1-11) 在 CD-1 小鼠中具有镇痛作用。

Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice.

Orphanin FQ (1-11) 醋酸盐，包含伤害肽的氨基酸1-11的肽片段，是ORL1/KOR-3受体的有效激动剂，Ki为55nM。孤儿素FQ是一种具有镇痛作用的NOP激动剂。

Orphanin FQ (1-11) acetate, the peptide fragment containing amino acids 1-11 of Nociceptin, is a potent agonist of the ORL1/KOR-3 receptor with a Ki of 55 nM. Orphanin FQ is a NOP agonist with analgesic effects.

伤害感受肽（1-11）（孤啡肽 FQ，或 OFQ/N）（1-11）是伤害感受肽的 N 端片段，用于探测 NOP 受体的部分激活。其序列保留了结合相关的关键芳香族和碱性残基。研究人员用它剖析 N 端对信号传导效能的贡献。该肽有助于伤害感受肽类似物的结构 - 活性分析。

Nociceptin (1-11), (Orphanin FQ, or OFQ/N) (1-11) is an N-terminal fragment of nociceptin used to probe partial activation of the NOP receptor. Its sequence preserves critical aromatic and basic residues involved in binding. Researchers employ it to dissect contribution of the N-terminus to signaling efficacy. The peptide aids structure–activity analysis of nociceptin analogs.

孤啡肽 FQ（1-11）是截短型神经肽，含有对早期受体结合基序至关重要的芳香族与疏水残基。其紧凑形式支持高分辨率结构研究。两亲性趋势影响膜相互作用。研究者用于最小基序探索。

Orphanin FQ (1-11) is a truncated neuropeptide containing aromatic and hydrophobic residues essential for early receptor-binding motifs. Its compact form supports high-resolution structural studies. Amphipathic tendencies influence membrane interactions. Researchers use it in minimal motif exploration.

Reinscheid RK, et al. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 1996;271(24):14163-14168. : https://pubmed.ncbi.nlm.nih.gov/8662940/
Rossi GC, et al. Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J Pharmacol Exp Ther. 1997;282(2):858-865. : https://pubmed.ncbi.nlm.nih.gov/9262352/