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一种小鼠酪氨酸酶相关蛋白 (TRP-2) 衍生肽,对应其 180-188 残基氨基酸序列。
编号:200730
CAS号:219312-69-3
单字母:H2N-SVYDFFVWL-OH
mTRP-2 (180-188) 是一种小鼠酪氨酸酶相关蛋白 (TRP-2) 衍生肽,对应其 180-188 残基氨基酸序列。TRP-2 (180-188) 被抗 B16 细胞毒性 T 淋巴细胞 (CTL) 识别为 TRP-2 的主要反应性表位。
mTRP-2 (180-188) is a murine tyrosinase-related protein 2 (TRP-2) -derived peptide, corresponding to residues 180-188. TRP-2 (180-188) is identified as the major reactive epitope within TRP-2 recognized by anti-B16 CTLs[1].
This peptide is derived from tyrosinase-related protein 2 (TRP2) residues 180-188. TRP2, also named L-dopachrome tautomerase, H-2KB or DCT, belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. Studies show that this TRP2 derived peptide can bind to mouse and human MHC class Imolecules. Immunization with TRP2 peptide loaded dendritic cells (DCs) results in effective induction of antitumor immunity
TRP‑2 (180‑188) 是一段肽片段,包含与色素相关生化通路相关的疏水与带电残基。其序列支持对蛋白质‑肽识别的研究。结构趋势可用于构象状态建模。研究人员将其用于黑色素相关酶网络调控基序研究。
TRP-2 (180-188) is a peptide fragment containing hydrophobic and charged residues relevant to pigment-associated biochemical pathways. Its sequence supports exploration of protein–peptide recognition. Structural tendencies allow modeling of conformational states. Researchers apply it to study regulatory motifs in melanin-related enzymatic networks.
| DOI | 名称 | |
|---|---|---|
| 10.1084/jem.185.3.453 | Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma | 下载 |





