400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
衍生自淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 糖蛋白 (GP) 的多肽片段，对应于 61-80 氨基酸序列。
编号：200705
CAS号：232598-19-5
单字母：H2N-GLKGPDIYKGVYQFKSVEFD-OH
<p>LCMV GP (61-80) 是衍生自淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 糖蛋白 (GP) 的多肽片段，对应于 61-80 氨基酸序列。LCMV GP (61-80) 是一种特异性抗原决定簇，可以诱导 CD4+ T 细胞反应。<br /> LCMV GP (61-80) is a peptide fragment derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), and corresponds to amino acids 61-80. LCMV GP (61-80) is a specific epitope which can induce CD4+ T-cell response[1][2][3].</p> <p>研究表明淋巴细胞脉络丛脑膜炎病毒感染可诱导较强的 T 辅助细胞应答（至少在 C57BL/6 小鼠中），几乎完全集中于两个表位 GP61‑80 与 NP309‑328，均由 I‑Ab 分子呈递。淋巴细胞脉络丛脑膜炎病毒 61‑80 肽优先作为 T 辅助表位，该表位的加工途径似乎不同（不依赖溶酶体途径），用于病毒细胞介导靶向。<br /> <br /> LCMV infection has been shown to induce a relatively strong T-helper response (at least in C57BL/6 mice) focused almost entirely upon two epitopes, GP61–80 and NP309–328, both of which are presented by I-Ab. The LCMV 61-80 peptide acts preferentially as an LCMV T helper epitope and this epitope seems to be processed differently (lysosomal-independent pathway) for viral cell-mediated targeting.</p>
Rodriguez F, et, al. CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting. J Virol. 2001 Nov; 75(21): 10421-30. : https://pubmed.ncbi.nlm.nih.gov/11581410/
Andargachew R, et, al. CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol. 2018 Jul 1; 201(1):19-30. : https://pubmed.ncbi.nlm.nih.gov/29777029/
Homann D, et, al. Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II. Virology. 2007 Jun 20; 363(1): 113-23. : https://pubmed.ncbi.nlm.nih.gov/17320138/
