BigLEN(rat) TFA 是脑内最丰富的多肽之一,是有效的 GPR171 激动剂,其EC50 值为1.6 nM。
BigLEN(rat) TFA, one of the most abundant peptides in brain, is a potent GPR171 agonist, with an EC50 of 1.6 nM[1][2].
Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. : https://pubmed.ncbi.nlm.nih.gov/30726666
Ivone Gomes, et al. GPR171 Is a Hypothalamic G Protein-Coupled Receptor for BigLEN, a Neuropeptide Involved in Feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. : https://pubmed.ncbi.nlm.nih.gov/24043826