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CALP2 是一种钙调蛋白 (CaM) 拮抗剂 (Kd 为 7.9 µM)，以亲和力结合 CaM EF-hand/Ca2+ 结合位点。CALP2 抑制 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性并增加细胞内 Ca2+ 浓度。CALP2 有效抑制粘附和脱粒。CALP2 还是肺泡巨噬细胞的强激活剂。
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].

类钙肽 2 是一种设计序列，含有模拟钙相关调控基序的带电残基。其构象支持金属响应折叠行为研究。疏水组分稳定结构转变。研究人员将其用于钙结合结构域的生化分析。

Calcium-like peptide 2 is a designed sequence containing charged residues that mimic calcium-associated regulatory motifs. Its conformation supports studies of metal-responsive folding behavior. Hydrophobic components stabilize structural transitions. Researchers apply it in biochemical analyses of calcium-binding domains.

R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. : https://pubmed.ncbi.nlm.nih.gov/11145661
R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. : https://pubmed.ncbi.nlm.nih.gov/11481245
Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84(1):29-40. : https://pubmed.ncbi.nlm.nih.gov/14631377
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