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转铁蛋白受体(TfR)靶向肽。它与TfR结合,并通过内吞作用内化为表达TfR的细胞。TfR靶向肽是小分子穿过血脑屏障运输到大脑或进入恶性组织的潜在载体。
编号:200505
CAS号:344618-30-0
单字母:H2N-THRPPMWSPVWP-OH
<p>TfR-T12 是一个能透过血脑屏障的转铁蛋白受体 (TfR) 的结合肽,显示出 nM 水平的结合活性。</p> <p>TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.</p> <p>TfR-T12是转铁蛋白受体(TfR)靶向肽。它与TfR结合,并通过内吞作用内化为表达TfR的细胞。TfR靶向肽是小分子穿过血脑屏障运输到大脑或进入恶性组织的潜在载体。</p> <p>The 12-mer peptide sequence is a transferrin receptor (TfR) targeting peptide. It binds to TfR and is internalized via endocytosis into TfR-expressing cells. TfR targeting peptide is a potential carrier for transportation of small molecules across the blood-brain barrier to the brain, or into malignant tissues.</p>
靶向多肽可以根据其功能和用途分为不同的类别。在PDC(多肽偶联药物)中,靶向多肽通常被分为细胞穿透肽和细胞靶向肽两大类。
细胞穿透肽:这类多肽能够跨越细胞膜,转运具有生物活性的大分子物质,如多肽、蛋白质、核酸等化学药物,使其顺利进入细胞。一些常见的细胞穿透肽包括Pep-1、Pentratin、PepFact14、Transportan等。
细胞靶向肽:这类多肽的作用主要是引导化学药物或生物活性分子与特定类型的细胞结合,以提高其靶向性和治疗效率。常见的细胞靶向肽包括PEGA、生长激素抑制素类似物、蛙皮素类似物、RGD肽类等。
| DOI | 名称 | |
|---|---|---|
| 10.1039/c8sc02415d | Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport | 下载 |
| 10.1186/s13075-021-02535-6 | Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study | 下载 |
| 10.1016/j.bioactmat.2020.12.010 | The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment | 下载 |
| 10.1016/j.apsb.2017.11.005 | Biomacromolecules as carriers in drug delivery and tissue engineering | 下载 |





