400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
肽T1是凝血酶受体结构域，其作为受体本身的束缚配体起作用。T1是凝血酶触发的血小板聚集，5-羟色胺释放和酪氨酸磷酸化的抑制剂。
编号：200383
CAS号：207553-92-2
单字母：H2N-MSRPACPNDKYE-OH
| 参考文献（References）: | J.Doorbar and G.Winter, J. Mol. Biol., 244, 361 (1994) H.Schafberg et al., Br. J. Cancer, 76, 1592 (1997) R.Kaufmann et al., NeuroReport, 9, 709 (1998) H.Y.Tang and D.W.Speicher, Anal. Biochem., 334, 48 (2004) M.C.Sun et al., J. Sep. Sci., 31, 538 (2008) |
肽T1是凝血酶受体结构域，其作为受体本身的束缚配体起作用。T1是凝血酶触发的血小板聚集，5-羟色胺释放和酪氨酸磷酸化的抑制剂。其抗聚集活性比先前报道的凝血酶受体肽拮抗剂高约十倍。该肽已在蛋白质修饰和MS研究中用作模型肽。
The peptide T1 is the thrombin receptor domain, which functions as a tethered ligand for the receptor itself. T1 is an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. This peptide has served as model peptide in protein modification and MS studies.
T1 是紧凑的肽基序，含有平衡疏水性和带电相互作用的残基，支持明确的二级结构采样。其最小结构能够进行高分辨率光谱分析。该序列提供短程折叠行为的见解。研究人员用它进行基序发现、结构建模和肽 - 蛋白质界面探索。
T1 is a compact peptide motif containing residues that balance hydrophobic and charged interactions to support defined secondary-structure sampling. Its minimal architecture enables high-resolution spectroscopic analysis. The sequence provides insight into short-range folding behavior. Researchers use it in motif discovery, structural modeling, and peptide-protein interface exploration.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.ab.2004.08.008 | Identification of alternative products and optimization of 2-nitro-5-thiocyanatobenzoic acid cyanylation and cleavage at cysteine residues | 下载 |
| 10.1002/jssc.200700440 | Matrix-assisted laser desorption/ionization-MS-based relative quantification of peptides and proteins using iodoacetamide and N-methyliodoacetamide as labeling reagents | 下载 |
| 10.1006/jmbi.1994.1736 | Isolation of a peptide antagonist to the thrombin receptor using phage display | 下载 |
| 10.1038/bjc.1997.602 | Thrombin has a bimodal effect on glioma cell growth | 下载 |
| 10.1097/00001756-199803090-00027 | Functional thrombin receptor PAR1 in primary cultures of human glioblastoma cells | 下载 |
