17665-02-0_二肽Leu-DLeu_H2N-Leu-DLeu-OH_H2N-Ll-OH_D型氨基酸肽_ 600+种二肽(Dipeptide)现货

二肽Leu-DLeu

编号：200191

CAS号：17665-02-0

单字母：H2N-Ll-OH

编号:	200191
中文名称:	二肽Leu-DLeu
中文同义词:	L-亮氨酰-D-亮氨酸,二水
英文名:	(R)-2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoicaciddihydrate
英文同义词:	(R)-2-((S)-2-amino-4-methylpentanamido)-4-methylpentanoicaciddihydrate、
CAS号:	17665-02-0
单字母:	H2N-Ll-OH
三字母:	H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Leu L-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -DLeu D型亮氨酸 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	2
分子式:	C₁₂H₂₄N₂O₃
平均分子量:	244.33
精确分子量:	244.18
等电点(PI):	-
pH=7.0时的净电荷数:	0.97
平均亲水性:	-1.8
疏水性值:	3.8
熔点:	267-270°C
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
储存条件:	负80℃至负20℃
标签:	D型氨基酸肽 600+种二肽(Dipeptide)现货

MDL号:	MFCD00066071
参考文献（References）:	<ALLPEPTIDE>Anand Sitaram, et al. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell. 2012 Aug;23(16):3178-92.<ALLPEPTIDE>Balraj Doray, et al. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Mol Biol Cell. 2007 May;18(5):1887-96.<ALLPEPTIDE>De Michael Chung, et al. Enantioselective molecular recognition between beta-sheets. J Am Chem Soc. 2004 Mar 17;126(10):3062-3.<ALLPEPTIDE>Griet Van Zeebroeck, et al. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol. 2009 Jan;5(1):45-52.<ALLPEPTIDE>Lesley Colgan, et al. Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter. Traffic. 2007 May;8(5):512-22.
TPSA:	155.42
LogP :	-0.6741
H_Acceptors:	3.0
H_Donors:	3.0
Rotatable_Bonds:	7.0
警示词:	Warning
危险申明:	H302-H315-H319-H335
警告申明:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
GHS编码:	GHS07
SMILES:	CC(C[C@@H](NC([C@@H](N)CC(C)C)=O)C(O)=O)C.O.O

H-Leu-D-Leu-OH is a nonproteinogenic amino acid that is used in the ALLPEPTIDEesis of proteins. It is formed from glutamic acid and leucine through an amide bond, and has a protonated amino group. The specificities of H-Leu-D-Leu are not yet known, but it has been shown to have antibacterial activity against Staphylococcus aureus and Streptococcus pyogenes. H-Leu-D-Leu may be transported across the cytoplasm membrane by means of a transport rate that is significantly higher than other amino acids. This amino acid also exhibits significant homology with nanosized molecules.

很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。

DOI	名称
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10.1016/0009-8981(77)90071-7	A new method for peptidase activity measurement in serum and tissues, using L-Leu-L-Leu as substrate	下载
10.1038/nnano.2008.378	Enzyme-assisted self-assembly under thermodynamic control	下载
10.1089/ast.2011.0755	The PROCESS experiment: exposure of amino acids in the EXPOSE-E experiment on the international space station and in laboratory simulations	下载
10.1021/acs.langmuir.5b02784	Reconstructive Phase Transition in Ultrashort Peptide Nanostructures and Induced Visible Photoluminescence	下载
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10.1128/AEM.71.12.7961-7973.2005	L-selective amidase with extremely broad substrate specificity from Ochrobactrum anthropi NCIMB 40321	下载