400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 174009 |
| 中文名称: | 三肽H-D-Pro-Phe-Arg-chloromethylketone |
| 英文名: | pFR-CMK |
| CAS号: | 88546-74-1 |
| 单字母: | H2N-pFR-CMK |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -DProD型脯氨酸 -PheL-苯丙氨酸：phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：F，Phe。 -ArgL-精氨酸：arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷，为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号：R，Arg。 -CMKC端氯甲基酮修饰，Chloromethylketone (CMK) |
| 氨基酸个数: | 3 |
| 分子式: | C21H31N6O3Cl1 |
| 平均分子量: | 450.96 |
| 精确分子量: | 450.21 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | 0.25 |
| 疏水性值: | -1.1 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 CMK(氯甲基酮)修饰 三肽 |
D-PFR-CMK, inhibitor of coagulation factor XII and plasma kallikrein.
H-D-Pro-Phe-Arg - 氯甲基酮三氟乙酸盐含有反应性氯甲基酮基团，用于催化残基的选择性共价修饰。其芳香与碱性组分影响底物模拟。该肽适用于机制酶捕获与动力学分析。应用包括蛋白酶研究与构效研究。
H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt incorporates a reactive chloromethylketone group for selective covalent modification of catalytic residues. Its aromatic and basic components influence substrate mimicry. The peptide is suited for mechanistic enzyme trapping and kinetic analysis. Applications include protease research and structure-activity studies.
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
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| 10.1186/ar606 | Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis | 下载 |
| 10.1182/blood-2008-04-144758 | Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment | 下载 |
| 10.1016/j.immuni.2011.02.008 | Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo | 下载 |
| 10.1111/jth.12663 | Single-chain factor XII exhibits activity when complexed to polyphosphate | 下载 |
| 10.1172/JCI77139 | Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III | 下载 |
| 10.1099/mic.0.046862-0 | Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system | 下载 |
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