一种细胞渗透性不可逆的前蛋白转化酶位点1蛋白酶抑制剂（S1P，也称为枯草杆菌蛋白酶kexin同工酶，SKI-1）。
编号：152418
CAS号：911379-57-2
单字母：Decanoicacid-RRLL-CMK
| 编号: | 152418 |
| 中文名称: | 四肽Decanoyl-Arg-Arg-Leu-Leu=Cmk |
| CAS号: | 911379-57-2 |
| 单字母: | Decanoicacid-RRLL-CMK |
| 三字母: | Decanoicacid 癸酸修饰、癸酰化 -ArgL-精氨酸：arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷，为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号：R，Arg。 -ArgL-精氨酸：arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷，为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号：R，Arg。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -CMKC端氯甲基酮修饰 |
| 氨基酸个数: | 4 |
| 分子式: | C35H67O5N10Cl1 |
| 平均分子量: | 743.42 |
| 精确分子量: | 742.5 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 2 |
| 平均亲水性: | 0.6 |
| 疏水性值: | -0.35 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CMK(氯甲基酮)修饰 |
A cell-permeable irreversible inhibitor of proprotein convertase site 1 protease (S1P, also called subtilisin kexin isozyme, SKI-1). Dec-RRLL-CMK efficiently blocked the processing of Lassa virus glycoprotein precursor at nanomolar concentrations, though the observed cytotoxicity of the inhibitor limits its application. Originally synthesized for Prof. Dr. W. Garten (April 2000).
| DOI | 名称 | |
|---|---|---|
| 10.1074/jbc.M513675200 | The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors | 下载 |
| 10.1371/journal.pntd.0000446 | Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants | 下载 |
| 10.1128/JVI.01697-09 | Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses | 下载 |
| 10.1074/jbc.M110.151647 | Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization | 下载 |
| 10.1038/jid.2013.282 | Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells | 下载 |
| 10.1016/0300-9084(94)90149-x | Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones | 下载 |
