400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 191655 |
| 中文名称: | 二肽Z-Leu-Tyr-chloromethylketone |
| CAS号: | 56979-35-2 |
| 单字母: | Z-LY-CMK |
| 三字母: | Cbz N端Cbz保护，苄氧羰基（Cbz，Z） -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -TyrL-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -CMKC端氯甲基酮修饰，Chloromethylketone (CMK) |
| 氨基酸个数: | 2 |
| 分子式: | C24H29O5N2Cl1 |
| 平均分子量: | 460.95 |
| 精确分子量: | 460.18 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1 |
| 平均亲水性: | -2.6 |
| 疏水性值: | 1.45 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CMK(氯甲基酮)修饰 CBZ修饰肽 600+种二肽(Dipeptide)现货 |
Z-LY-CMK, E.coli ClpP inhibitor.
Z-Leu-Tyr-chloromethylketone is a peptide that binds to the reticulum and prevents the release of calcium ions. It is a chloromethyl ketone, which inhibits the L-type calcium channels in cells. Z-Leu-Tyr-chloromethylketone has been shown to block the influx of calcium ions into cytosolic compartments. This process leads to inhibition of protein synthesis and cell death by apoptosis.
Z‑Leu‑Tyr‑氯甲基酮是一种肽类似物，带有反应性氯甲基酮部分，适合靶向活性位点修饰。芳香族与疏水残基有助于选择性结合。保护化学稳定序列。研究人员用于机制酶研究。
Z-Leu-Tyr-chloromethylketone is a peptide analog carrying a reactive chloromethylketone moiety suited for targeted active-site modification. Aromatic and hydrophobic residues contribute to selective binding. Protective chemistry stabilizes the sequence. Researchers use it to investigate catalytic mechanisms.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.jsb.2006.03.013 | Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site | 下载 |
| 10.1016/j.devcel.2007.07.016 | ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans | 下载 |
| 10.1021/ja4082793 | Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition | 下载 |
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