400-998-5282
专注多肽 服务科研

| 编号: | 128713 |
| 中文名称: | Adropin (34-76) (human, mouse, rat) |
| CAS号: | 1802086-30-1 |
| 三字母: | Cys-His-Ser-Arg-Ser-Ala-Asp-Val-Asp-Ser-Leu-Ser-Glu-Ser-Ser-Pro-Asn-Ser-Ser-Pro-Gly-Pro-Cys-Pro-Glu-Lys-Ala-Pro-Pro-Pro-Gln-Lys-Pro-Ser-His-Glu-Gly-Ser-Tyr-Leu-Leu-Gln-Pro(Disulfide bond) |
| 来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 未分类肽 |
Adropin is a secreted factor involved in energy homeostasis and lipid metabolism. It is encoded by the energy homeostasis associated gene (Enho) and is expressed in liver and brain. In diet-induced obesity (DIO) mice Adropin (34-76) attenuated hepatosteatosis and insulin reistance independently of adiposity or food intake. Additionally, adropin could be a regulator of endothelial function.
降脂肽(34‑76)(人、小鼠、大鼠)三氟乙酸盐代表该肽的保守区域,用于探索代谢信号框架。其两亲性序列支持跨物种折叠分析与受体结合研究。该片段有助于研究肽 - 蛋白通讯的结构决定因素。应用包括生物合成研究与肽工程。
Adropin (34-76) (human, mouse, rat) trifluoroacetate salt represents a conserved region of the peptide used to explore metabolic signaling frameworks. Its amphipathic sequence supports folding analyses and receptor-binding studies across species. The fragment aids in studying structural determinants of peptide-protein communication. Applications include biosynthesis research and peptide engineering.
Adropin (34-76) 是 Adropin 的分泌结构域。Adropin (34-76) 在肝细胞中可抑制cAMP 水平和葡萄糖生成,具有降血糖的作用。Adropin (34-76) 通过抑制 GLI1 信号通路发挥抗纤维化的作用。 体外研究: Adropin (34-76) (100 nM;3 小时) 在原代培养的小鼠肝细胞中抑制葡萄糖生成[1]。 Adropin (34-76) (100 nM;3 小时) 在 HepG2 肝细胞中降低 cAMP 水平[1]。 Adropin (34-76) (0-100 ng/mL;48 小时) 在成纤维细胞中抑制 TGF-β 诱导的细胞活化、胶原蛋白的产生和纤维化重塑[2]。 Adropin (34-76) (100 ng/mL;48 小时) 在成纤维细胞中通过抑制 GLI1 信号通路发挥抗纤维化的作用[2]
| DOI | 名称 | |
|---|---|---|
| 10.1161/CIRCULATIONAHA.109.931782 | Adropin is a novel regulator of endothelial function | 下载 |
| 10.1111/1755-5922.12025 | Deficiency of a new protein associated with cardiac syndrome X; called adropin | 下载 |
| 10.2337/db14-0388 | Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin | 下载 |





