1926163-57-6_MALT1 抑制剂、MALT1 Inhibitor_Cbz-Val-Arg-Pro-DArg-FMK_Z-VRPr-FMK_D型氨基酸肽_ CBZ修饰肽_ FMK修饰肽

MALT1 抑制剂、MALT1 Inhibitor
对半胱氨酸蛋白酶MALT1的细胞渗透性，不可逆抑制剂。

编号：145606

CAS号：1926163-57-6

单字母：Z-VRPr-FMK

编号:	145606
中文名称:	MALT1 抑制剂、MALT1 Inhibitor
英文名:	Z-VRPR-FMK,
CAS号:	1926163-57-6
单字母:	Z-VRPr-FMK
三字母:	Cbz N端Cbz保护，苄氧羰基（Cbz，Z） -Val L-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -Arg L-精氨酸：arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷，为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号：R，Arg。 -Pro L-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -DArg D型精氨酸 -FMK C端氟甲基酮修饰，Fluoromethylketone (FMK)
氨基酸个数:	4
分子式:	C₃₁H₄₉O₆N₁₀F₁
平均分子量:	676.78
精确分子量:	676.38
等电点(PI):	-
pH=7.0时的净电荷数:	2
平均亲水性:	1.5
疏水性值:	-1.6
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
储存条件:	负80℃至负20℃
标签:	D型氨基酸肽 CBZ修饰肽 FMK修饰肽

Cell-permeable, irreversible inhibitor of para-caspase MALT1. Z-VRPR-FMK is based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9.

Z-VRPR-FMK trifluoroacetate is an apoptosis-inducing inhibitor that works by inhibiting a specific kinase in the human body. It has been shown to have anti-cancer properties and may be useful in the treatment of various types of cancer. Z-VRPR-FMK trifluoroacetate is a menthol analog that acts as an inhibitor of apoptosis, which is the process by which cells die naturally. This compound has been tested on Chinese hamster ovary cells and has been found to be effective at inducing apoptosis in these cells. Additionally, Z-VRPR-FMK trifluoroacetate has been shown to inhibit tylosin-induced apoptosis in human colon cancer cells. Overall, this compound shows promise as a potential therapeutic agent for the treatment of cancer and other diseases.

很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。

DOI	名称
10.1016/j.jmb.2006.09.010	Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9	下载
10.1038/ni1568	The proteolytic activity of the paracaspase MALT1 is key in T cell activation	下载
10.1038/ni.2540	The protease activity of the paracaspase MALT1 is controlled by monoubiquitination	下载
10.1007/978-1-4939-0357-3_11	Detection and measurement of paracaspase MALT1 activity	下载
10.1371/journal.pone.0103774	MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes	下载