400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 131282 |
| 中文名称: | 二肽H-Glu(Leu-OH)-OH |
| 英文名: | H-γ-Glu-Leu-OH |
| CAS号: | 2566-39-4 |
| 单字母: | H2N-γGlu-L-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -γGluγ谷氨酸 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C11H20N2O5 |
| 平均分子量: | 260.29 |
| 精确分子量: | 260.14 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | 0.6 |
| 疏水性值: | 0.15 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 氨基酸衍生物肽 600+种二肽(Dipeptide)现货 |
H-Glu(Leu-OH)-OH is a postprandial plasma metabolite that is produced by the hydrolysis of proteins and peptides. The profile of H-Glu(Leu-OH)-OH in plasma can be used to characterize the metabolism of these compounds and has been found to be useful for the diagnosis of metabolic disorders. H-Glu(Leu-OH)-OH levels are increased in patients with metabolic syndrome, obesity, diabetes mellitus type 2, chronic kidney disease, and cancer. This metabolite can also be used as an indicator for bacterial enzyme activity in the gut. H-Glu(Leu-OH)-OH levels are correlated with glutamate and sodium hydroxide solution levels in plasma or urine samples. H-Glu(Leu-OH)-OH may play a role in the pathogenesis of cancer due to its ability to inhibit DNA synthesis and protein synthesis.
γ-Glu-Leu is a main contributor to the "kokumi" taste of edible beans (Phaseolus vulgaris L.). γ-Glu-Leu and further kokumi-active γ-glutamyl dipeptides have been isolated from mature Gouda cheese. The branched dipeptides are responsible for the complex taste of the cheese.
