400-998-5282
专注多肽 服务科研

编号:592544
CAS号:
单字母:DOTA-Pra-GG-K(N3)-GGEEQRLGNQWAVGHLM-OH
专肽生物提供多种叠氮化修饰类型,以满足丰富的多肽研究。
1、叠氮乙酸,常标记于N端
2、叠氮丙酸,常标记于N端
3、叠氮丁酸,常标记于N端
4、叠氮戊酸,常标记于N端
5、叠氮己酸,常标记于N端
6、N3-PEGn-COOH,常见的为N3-PEG2-COOH、N3-PEG4-COOH、N3-PEG6-COOH,常标记于N端
若在C端添加赖氨酸,以上6种均可添加到赖氨酸的侧链,以实现多肽C端叠氮化修饰。
7、H2N-PEGn-N3,常见的H2N-PEG2-N3、H2N-PEG4-N3、H2N-PEG6-N3,常标记于C端。
以下展示下多肽标记的大致结构。
1、
2、
3、
4、
5、
6、如N3-PEG2-COOH修饰

7、如H2N-PEG4-N3修饰

DOTA说明:
1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid (DOTA) is a common metal chelator used as a complexing agent for lanthanide ions and other metal ions. Its complexes have applications as contrast agents and cancer treatments.
DOTA修饰肽相关文献:
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Preliminary Therapy Evaluation of 225Ac-DOTA-c (RGDyK) Demonstrates that Cerenkov Radiation Derived from 225Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization.Pandya, Darpan N., et al. Theranostics 6.5 (2016): 698.
Cyclotron Production of High–Specific Activity 55 Co and In Vivo Evaluation of the Stability of 55 Co Metal-Chelate-Peptide Complexes.
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