| 编号: | 147072 |
| 中文名称: | CMK修饰肽：H-DPhe-Pro-Arg-CMK |
| 英文名: | H-DPhe-Pro-Arg-CMK |
| 英文同义词: | H-D-Phe-Pro-Arg-chloromethylketone |
| CAS号: | 71142-71-7 |
| 单字母: | H2N-fPR-CMK |
| 三字母: | H2N N端氨基 -DPheD型笨丙氨酸 -Pro脯氨酸 -Arg精氨酸 -CMKC端氯甲基酮修饰 |
| 氨基酸个数: | 3 |
| 分子式: | C21H31N6O4l1 |
| 平均分子量: | 431.51 |
| 精确分子量: | 431.24 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | 0.25 |
| 疏水性值: | -1.1 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 CMK(氯甲基酮)修饰 三肽 |
一种高效的凝血酶和姜黄素R不可逆抑制剂。
PPACK, fPR-CMK, a highly effective irreversible inhibitor of thrombin and gingipain R.
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
| 10.1021/bi0116893 | Role of procoagulant lipids in human prothrombin activation. 1. Prothrombin activation by factor X(a) in the absence of factor V(a) and in the absence and presence of membranes | 下载 |
| 10.1021/bi026878f | Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies | 下载 |
| 10.1046/j.1538-7836.2003.00250.x | FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth | 下载 |
| 10.1046/j.1538-7836.2003.00404.x | Impaired healing of cutaneous wounds and colonic anastomoses in mice lacking thrombin-activatable fibrinolysis inhibitor | 下载 |
| 10.1111/j.1432-1033.2004.04367.x | Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II: effects on enzyme inhibition | 下载 |
| 10.1128/IAI.73.3.1506-1514.2005 | Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis | 下载 |
| 10.1111/j.1538-7836.2005.01322.x | Role of isoleucine residues 182 and 183 in thrombin-activatable fibrinolysis inhibitor | 下载 |
| 10.1111/j.1538-7836.2005.01647.x | Proteolytic cleavage of protein S during the hemostatic response | 下载 |
| 10.1016/j.exppara.2006.02.010 | Boophilus microplus: its saliva contains microphilin, a small thrombin inhibitor | 下载 |
| 10.1111/j.1574-6968.2006.00458.x | Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases | 下载 |
| 10.1021/bi800235r | Transmembrane domain interactions and residue proline 378 are essential for proper structure, especially disulfide bond formation, in the human vitamin K-dependent gamma-glutamyl carboxylase | 下载 |
| 10.2741/3176 | Hemostatic effects of recombinant DisBa-01, a disintegrin from Bothrops alternatus | 下载 |
| 10.1097/MBC.0b013e3283177b43 | Platelet microparticle suppressing antibody against GP Ibalpha acts independently of the filamin cleavage and increases protein tyrosine phosphorylation | 下载 |
| 10.1016/j.bbadis.2013.01.003 | Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C | 下载 |
| 10.1021/bi400142s | Multiple exosites distributed across the three domains of streptokinase co-operate to generate high catalytic rates in the streptokinase-plasmin activator complex | 下载 |
| 10.1160/TH13-12-1013 | Thrombin-induced platelet activation via PAR4: pivotal role for exosite II | 下载 |
| 10.1016/j.ab.2017.04.016 | Continuous-flow injection microfluidic thrombin assays: The effect of binding kinetics on observed enzyme inhibition | 下载 |
| 10.1016/0049-3848(94)90024-8 | Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK) | 下载 |
| 10.1128/AAC.45.10.2871-2876.2001 | Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues | 下载 |
| 10.1074/jbc.M309164200 | Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry | 下载 |
| 10.1002/ajh.20108 | Association of functional thrombin-activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population | 下载 |
| 10.1074/jbc.M610015200 | Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B | 下载 |
