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Ac-LLM-CHO (ALLM) is a potent competitive inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).

Peptide Ac-LLM-CHO is a Research Peptide with significant interest within the field academic and medical research. Recent citations using Ac-LLM-CHO include the following: Cost-Effective Online Multi-LLM Selection with Versatile Reward Models X Dai , J Li, X Liu, A Yu, J Lui - arXiv preprint arXiv:2405.16587, 2024 - arxiv.orghttps://arxiv.org/abs/2405.16587 Subtle differences in initial membrane interactions underpin the selectivity of small antimicrobial peptides S Praporski, A Mechler , F Separovic - ChemPlusChem, 2015 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cplu.201402318 Bioinfo-Bench: A Simple Benchmark Framework for LLM Bioinformatics Skills Evaluation Q Chen, C Deng - bioRxiv, 2023 - biorxiv.orghttps://www.biorxiv.org/content/10.1101/2023.10.18.563023.abstract Protein kinase C-ÎŽ isoform mediates lysosome labilization in DNA damage-induced apoptosis N Parent, M Scherer, G Liebisch - International , 2011 - spandidos-publications.comhttps://www.spandidos-publications.com/ijo/38/2/313 Can large language models predict antimicrobial peptide activity and toxicity? M Orsi , JL Reymond - RSC Medicinal Chemistry, 2024 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2024/md/d4md00159a Computer-aided design of beta-sheet peptides M Lopez , E Lacroix, M RamÃ\x84±Ã\x8cÂ\x81rez-Alvarado - Journal of molecular , 2001 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0022283601949186 ProLLM: Protein Chain-of-Thoughts Enhanced LLM for Protein-Protein Interaction Prediction M Jin, X Haochen , Z Wang , B Kang, R Ye, K Zhou - bioRxiv, 2024 - biorxiv.orghttps://www.biorxiv.org/content/10.1101/2024.04.18.590025.abstract Lactacystin, an inhibitor of the proteasome, blocks the degradation of a mutant precursor of glycosylphosphatidylinositol-linked protein in a pre-Golgi compartment K Oda, Y Ikehara, S Omura - Biochemical and biophysical research , 1996 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X96903149 Tx-LLM: A Large Language Model for Therapeutics JMZ Chaves, E Wang, T Tu , ED Vaishnav - arXiv preprint arXiv , 2024 - arxiv.orghttps://arxiv.org/abs/2406.06316 Intact proteins can bind to class II histocompatibility molecules with high affinity HA Runnels, DA Weber, JC Moore, LE Westerman - Molecular , 1997 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0161589097000436 Membrane mediated antimicrobial and antitumor activity of cathelicidin 6: Structural insights from molecular dynamics simulation on multi-microsecond scale BR Sahoo , T Fujiwara - PLoS One, 2016 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158702 Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex A Vinitsky , C Michaud, JC Powers , M Orlowski - Biochemistry, 1992 - ACS Publicationshttps://pubs.acs.org/doi/pdf/10.1021/bi00154a014 Peptide folding and aggregation studied using a simplified atomic model A Irback - Journal of Physics: Condensed Matter, 2005 - iopscience.iop.orghttps://iopscience.iop.org/article/10.1088/0953-8984/17/18/012/meta

Ac-Leu-Leu-Met-H (Aldehyde) is a tetrazolium dye that is used as a biological stain for the detection of bacteria in infectious diseases. It binds to toll-like receptor 4 on macrophages and other cells, which triggers a cascade of events leading to bacterial cell lysis. Aldehyde also has been shown to be an autophagy inducer and can cause neuronal death when administered in high doses.