脯氨酰内肽酶（PEP）的强效抑制剂，PEP是一种胞浆丝氨酸内切蛋白酶（IC 50 ＝ 120 nM）。
编号：170415
CAS号：86925-97-5
单字母：Z-PP-CHO
| 编号: | 170415 |
| 中文名称: | 二肽脯氨酰内肽酶抑制剂 II：Z-Pro-Pro-醛基化 |
| 英文名: | Prolyl endopeptidase Inhibitor II; Z-Pro-Pro-CHO |
| CAS号: | 86925-97-5 |
| 单字母: | Z-PP-CHO |
| 三字母: | Cbz N端Cbz保护 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -CHOC端醛基化 |
| 氨基酸个数: | 2 |
| 分子式: | C18H22O4N2 |
| 平均分子量: | 330.38 |
| 精确分子量: | 330.16 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | - |
| 疏水性值: | -1.6 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 醛肽 CBZ修饰肽 二肽(Dipeptide) |
Z-PP-CHO dimethylacetal was shown to be a potent inhibitor of prolyl endopeptidase (PEP), a cytoplasmic serine endoprotease (IC₅₀= 120 nM). It is suggested that PEP inhibitors could be useful for the treatment of cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.jneumeth.2011.11.011 | In situ prolyl oligopeptidase activity assay in neural cell cultures | 下载 |
| 10.1007/s11010-013-1778-4 | Structure-activity relationships of αs-casein peptides with multifunctional biological activities | 下载 |
| 10.1038/srep30980 | Addressing proteolytic efficiency in enzymatic degradation therapy for celiac disease | 下载 |
| 10.1002/glia.20645 | Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity | 下载 |
| 10.1016/j.peptides.2008.05.005 | Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein | 下载 |
