73392-19-5_标记肽Tos-GPK-对硝基苯胺_Tos-Gly-Pro-Lys-pNA_Tos-GPK-pNA_pNA修饰肽_ 三肽

标记肽Tos-GPK-对硝基苯胺
显色丝氨酸蛋白酶底物，例如,为类胰蛋白酶。Tos-GPK-pNA 已用于检测牛十二糖苷酶。

编号：139154

CAS号：73392-19-5

单字母：Tos-GPK-pNA

编号:	139154
中文名称:	标记肽Tos-GPK-对硝基苯胺
英文名:	Tos-Gly-Pro-Lys-pNA
CAS号:	73392-19-5
单字母:	Tos-GPK-pNA
三字母:	Tos 对甲苯磺酰基 -Gly 甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -Pro L-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -Lys L-赖氨酸：lysine。系统命名为(2S)-6-二氨基已酸。是编码氨基酸中的碱性氨基酸，哺乳动物的必需氨基酸。在蛋白质中的赖氨酸可以被修饰为多种形式的衍生物。符号：K，Lys。 -pNA 对硝基苯胺
氨基酸个数:	3
分子式:	C₂₆H₃₄O₇S₁N₆
平均分子量:	574.65
精确分子量:	574.22
等电点(PI):	-
pH=7.0时的净电荷数:	1
平均亲水性:	3
疏水性值:	-1.97
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
盐体系:	可选TFA、HAc、HCl或其它
储存条件:	负80℃至负20℃
标签:	pNA修饰肽 三肽

Chromogenic serine protease substrate, e.g. for tryptase. Tos-GPK-pNA has been used for assaying bovine duodenase.

Tos-Gly-Pro-Lys-pNA acetate is a peptide that has been shown to have inhibitory effects on serine proteases, such as fibrinogen. Tos-Gly-Pro-Lys-pNA acetate binds to the active site of serine proteases, which inhibits their activity and prevents them from cleaving fibrinogen. The rate of reaction is dependent on the concentration of enzyme inhibitors. For example, at low concentrations, the enzyme inhibitor will bind to only one or two sites on the serine protease, while at high concentrations it may bind to many sites. This molecule has been shown to be a potent inhibitor of human immunodeficiency virus (HIV) protease and is currently being studied for its use as a potential antiviral agent.

DOI	名称
10.1002/bip.22184	Hybrid analogues of SFTI-1 modified in P₁ position by β- and γ-amino acids and N-substituted β-alanines	下载
10.1042/bj2480821	Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides	下载
10.1016/0304-4165(89)90068-8	Effect of histamine and divalent cations on the activity and stability of tryptase from human mast cells	下载
10.1016/s0076-6879(81)80030-4	Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates	下载
10.1183/09031936.97.10010038	Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus	下载