400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
Component of coffee flavor
编号：126619
CAS号：2854-40-2
单字母：cyclo(PV)(main chain cyclo)
| 编号: | 126619 |
| 中文名称: | 环二肽cyclo(Pro-Val) |
| 英文名: | c(Pro-Val) |
| 英文同义词: | c(Val-Pro)、cyclo(Val-Pro) |
| CAS号: | 2854-40-2 |
| 单字母: | cyclo(PV)(main chain cyclo) |
| 三字母: | cyclo(Pro-Val)(main chain cyclo) |
| 氨基酸个数: | 2 |
| 分子式: | C10H16N2O2 |
| 平均分子量: | 196.25 |
| 精确分子量: | 196.12 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.5 |
| 疏水性值: | 1.3 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 修饰类型: | 酰胺键成环 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 200+种环二肽现货 现货多肽 |
Component of coffee flavor
Cyclo(-Pro-Val) is a type of natural product that has been shown to inhibit the growth of tumor cells. Cyclo(-Pro-Val) is a metabolite produced by the fungus Cryptococcus neoformans and may serve as a potential anti-cancer drug. The compound blocks mitochondrial membrane potential, which prevents cancer cells from multiplying. Cyclo(-Pro-Val) has also been shown to inhibit the growth of bacteria such as Pseudomonas aeruginosa and Burkholderia cepacia complex, although it has little or no effect on other types of bacteria and fungi.
环二肽又叫2,5-二酮哌嗪的衍生物,作为环肽成员中最小的一类环肽，专肽生物有部分环二肽的现货，也可以根据实验需求，定制含D型与L型，S与R构型的氨基酸。
Cyclo(Pro-Val) and other Pro-containing diketopiperazines were detected in roasted coffee. The amount of these compounds increases with the intensity of roasting, they contribute to the bitterness of taste. The bitter-tasting cyclodipeptide has also been detected in other foodstuffs as cocoa, chocolate, beef, and cheese. Cyclo(Pro-Val), which shows antifungal activity, has also been isolated from microorganisms and further natural sources.
R.Ortiz-Castro et al., Proc. Natl. Acad. Sci. USA, 108, 7253 (2011)；http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21482761
L.Yang et al., Tetrahedron Lett., 43, 6545 (2002)
M.Ginz and U.H.Engelhardt, Eur. Food . Res. Technol., 213, 8 (2001)
