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α-因子交配信息素,酵母醋酸酯是酿酒酵母α细胞通过Ste2p受体分泌的十三肽,有助于调节酵母中的交配。
编号:144929
CAS号:59401-28-4/189064-09-3
单字母:H2N-WHWLQLKPGQPMY-OH
| 参考文献(References): | D.Stötzler et al., Eur. J. Biochem., 69, 397 (1976) Y.Masui et al., Biochem. Biophys. Res. Commun., 78, 534 (1977) E.Ciejek et al., Biochem. Biophys. Res. Commun., 78, 952 (1977) T.Tanaka et al., J. Biochem., 82, 1681 (1977) T.Tanaka and H.Kita, Biochem. Biophys. Res. Commun., 83, 1319 (1978) Y.Masui et al., Biochem. Biophys. Res. Commun., 86, 982 (1979) H.H.Liao and J.Thorner, Proc. Natl. Acad. Sci. USA, 77, 1898 (1980) G.P.Samokhin et al., Exp. Cell Res., 131, 267 (1981) D.B.Finkelstein and L.McAlister, J. Biol. Chem., 256, 2561 (1981) O.Emter et al., Biochem. Biophys. Res. Commun., 116, 822 (1983) F.Naider and J.M.Becker, CRC Crit. Rev. Biochem., 21, 225 (1986) Lee, BK. et al. J. Biol. Chem. 276, 37950 (2001) Mayrhofer, S. and S. Pöggeler Eukaryot. Cell 4, 661 (2005). |
| 溶解度: | Soluble in water |
α-Factor Mating Pheromone, yeast 是一种十三肽,由 S. cerevisiae 的 α 细胞分泌产生,通过 Ste2p 受体起作用。
α-Factor Mating Pheromone, yeast is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor.
α-因子交配信息素,酵母醋酸酯是酿酒酵母α细胞通过Ste2p受体分泌的十三肽,有助于调节酵母中的交配。
α-Factor Mating Pheromone, yeast acetate is a tridecapeptide secreted by Saccharomyces cerevisiae α cells via the Ste2p receptor, which facilitates in regulating the mating in yeast.
α因子信息素使酵母细胞停滞在细胞周期的G1期,从而使相反交配型的细胞能够同步。α因子交配信息素诱导交配基因的表达,改变核结构,并使生长向交配伴侣极化。STE2编码酵母中交配型A细胞上发现的α因子信息素跨膜G蛋白偶联受体(GPCR)。α因子与Ste2结合并激活原型丝裂原活化蛋白激酶(MAPK)级联反应。信息素的暴露剂量不同,会激活MAPK Fus3产生不同的效果。高剂量的α因子会导致生长停滞和形成交配用的黏液,低剂量则会导致细胞生长延长。
The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle, this allows the opposite mating type cells to synchronise. Alpha factor mating pheromone induces the expression of mating genes, changes in nuclear architecture, and polarizes growth toward the mating partner. STE2 encodes the alpha factor pheromone transmembrane G-protein coupled receptor (GPCR) found on mating-type-A cells in yeast. Alpha factor binds Ste2 and activates prototypic mitogen-activated protein kinase (MAPK) cascade. The dose of pheromone exposure differentially activates the MAPK Fus3 for alternate effects. A high dose of alpha factor leads to growth arrest and schmooing formation for mating, a lower dose causes elongated cell growth.
α-交配因子是一种属于配体组的肽。研究表明,它能以高亲和力与雄激素受体结合,并作为该受体的激活剂。α-交配因子还能与β-肾上腺素能受体结合。该蛋白已被证明具有离子通道活性,这可能是由于其对钾通道的抑制作用。在研究中,α-交配因子被用作研究细胞生物学和细胞信号传导途径的工具。
Alpha-Mating Factor is a peptide that belongs to the group of ligands. It has been shown to bind to the androgen receptor with high affinity and act as an activator for this receptor. Alpha-Mating Factor is also able to bind to the beta-adrenergic receptor. This protein has been shown to have ion channel activity, which may be due to its inhibition of potassium channels. Alpha-Mating Factor is used in research as a tool for studying cell biology and cell signalling pathways.
α-交配因子醋酸盐是一种复杂的化合物,可用作有用的中间体、构建块和反应组分。α-交配因子醋酸盐已被证明是合成其他化合物的有用支架。它也可用作研究中的试剂或特种化学品。α-交配因子醋酸盐可溶于水和大多数有机溶剂,使其在应用中具有广泛的用途。
Alpha-Mating Factor acetate salt is a complex compound that is a useful intermediate, building block, and reaction component. Alpha-Mating Factor acetate salt has been shown to be a useful scaffold for the synthesis of other compounds. It can also be used as a reagent in research or as a speciality chemical. Alpha-Mating Factor acetate salt is soluble in water and most organic solvents, making it versatile in its applications.
这种三肽是酿酒酵母(Saccharomyces cerevisiae)的一种α因子信息素,通过与Ste2p结合诱导酵母发生接合。其同源G蛋白偶联受体(GPCR)激活一条G蛋白信号通路,该通路与哺乳动物信号通路高度保守。
This tridecapeptide, an alpha-factor pheromone of Saccharomyces cerevisiae, induces conjugation in yeast by binding to Ste2p. Its cognate GPCR activates a G protein signal pathway that highly conserves with mammalian signaling pathways.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.peptides.2003.11.028 | The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors | 下载 |
| 10.1016/0092-8674(83)90186-1 | Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor | 下载 |





