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专注多肽 服务科研

| 编号: | 154168 |
| 中文名称: | 二肽Trp-Pro |
| 中文同义词: | L-色氨酸-L-脯氨酸 |
| 英文名: | Trp-Pro |
| 英文同义词: | L-tryptophyl-L-proline、H-Trp-Pro-OH |
| CAS号: | 38136-75-3 |
| 单字母: | H2N-WP-OH |
| 三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。 -TrpL-色氨酸:tryptophan[e]。系统命名为(2S)-氨基-3-(3-吲哚基)丙酸。是编码氨基酸,哺乳动物的必需氨基酸。符号:W,Trp。某些抗菌素中含有 D-色氨酸。 -ProL-脯氨酸:proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用,如易形成顺式的肽键等。符号:P,Pro。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C16H19N3O3 |
| 平均分子量: | 301.34 |
| 精确分子量: | 301.14 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -3.4 |
| 疏水性值: | -1.25 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 5500 |
| 来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| TPSA: | 99.42 |
| LogP : | 1.1133 |
| H_Acceptors: | 3.0 |
| H_Donors: | 3.0 |
| Rotatable_Bonds: | 4.0 |
| SMILES: | C1C[C@H](N(C1)C(=O)[C@H](CC2=CNC3=CC=CC=C32)N)C(=O)O |
H-Trp-Pro-OH is an amide that can be used as a model system in the preparation of collagen. It has been shown to inhibit the linker between collagen molecules, which may lead to the formation of proline-rich peptides. H-Trp-Pro-OH has also been found to have anticancer properties, and inhibits cancer cell growth by inhibiting protein synthesis and promoting apoptosis. H-Trp-Pro-OH was found to inhibit cancer cells through a mechanism that is not yet fully understood, but it may involve both competitive inhibition of amino acids and activation of apoptosis through reactive oxygen species.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.chembiol.2008.05.019 | Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus | 下载 |
| 10.1016/j.foodchem.2012.02.183 | Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran | 下载 |
| 10.1021/jf303146h | Amino acids and peptides activate at least five members of the human bitter taste receptor family | 下载 |
| 10.1016/s0021-9673(01)01543-6 | Cutinase-peptide fusions in thermoseparating aqueous two-phase systems. Prediction of partitioning and enhanced tag efficiency by detergent addition | 下载 |
| 10.1021/jp809857y | Dependence of the AmII'p proline Raman band on peptide conformation | 下载 |





