400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
编号：127005
CAS号：19943-27-2
单字母：cyclo(PP)(main chain cyclo)
| 编号: | 127005 |
| 中文名称: | 维格列汀杂质 cis-cyclo(Pro-Pro)、环二肽cyclo(Pro-Pro) |
| 英文名: | cyclo(Pro-Pro)、cis-cyclo(Pro-Pro) |
| CAS号: | 19943-27-2 |
| 单字母: | cyclo(PP)(main chain cyclo) |
| 三字母: | cyclo(Pro-Pro)(main chain cyclo) |
| 氨基酸个数: | 2 |
| 分子式: | C10H14N2O2 |
| 平均分子量: | 194.23 |
| 精确分子量: | 194.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | - |
| 疏水性值: | -1.6 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 修饰类型: | 酰胺键成环 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 200+种环二肽现货 现货多肽 |
"Cyclo(L-Pro-L-Pro) is a cyclic peptide that was first synthesized in 1968 by the chemists, K. Brown and H. M. Schuster. Cyclo(L-Pro-L-Pro) has been shown to produce p-hydroxybenzoic acid, an intermediate in the metabolism of dopamine, when incubated with human serum or human erythrocytes. In addition, it has been shown to increase locomotor activity and enzyme activities in rats, as well as cytosolic calcium levels in cells. This compound may be a useful experimental model for studying Parkinsons disease because of its ability to inhibit dopamine uptake and increase the production of dopamine from its precursor L-DOPA. It also binds to neurokinin 1 receptor (NK1R), which is involved in inflammatory responses and pain sensation."
环二肽又叫2,5-二酮哌嗪的衍生物,作为环肽成员中最小的一类环肽，专肽生物有部分环二肽的现货，也可以根据实验需求，定制含D型与L型，S与R构型的氨基酸。
