400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 参考文献（References）: | 1. Nederpelt, I., Georgi, V., Schiele, F., et al . Characterization of 12 GnRH peptide agonists - a kinetic perspective . Br. J. Pharmacol. 173(1), 128-141 (2016) . <ALLPEPTIDE>2. Osawa, T., Nakao, T., Kimura, M., et al . Fertirelin and buserelin compared by LH release, milk progesterone and subsequent reproductive performance in dairy cows treated for follicular cysts . Theriogenology 44(6), 835-847 (1995) . |
| 溶解度: | DMSO: Sparingly Soluble: 1-10 mg/ml PBS pH 7.2: Soluble: ≥10 mg/ml |
| SMILES: | O=C([C@H]1NC(CC1)=O)N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(NCC)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CNC6=CC=CC=C56)=O |
| InChI/InChI Code: | InChI=1S/C55H76N16O12/c1-4-59-53(82)44-12-8-20-71(44)54(83)38(11-7-19-60-55(56)57)66-49(78)39(21-30(2)3)65-46(75)27-62-47(76)40(22-31-13-15-34(73)16-14-31)67-52(81)43(28-72)70-50(79)41(23-32-25-61-36-10-6-5-9-35(32)36)68-51(80)42(24-33-26-58-29-63-33)69-48(77)37-17-18-45(74)64-37/h5-6,9-10,13-16,25-26,29-30,37-44,61,72-73H,4,7-8,11-12,17-24,27-28H2,1-3H3,(H,58,63)(H,59,82)(H,62,76)(H,64,74)(H,65,75)(H,66,78)(H,67,81)(H,68,80)(H,69,77)(H,70,79)(H4,56,57,60)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 |
| InChI Key: | DGCPIBPDYFLAAX-YTAGXALCSA-N |
| Formal Name: | 9-(N-ethyl-L-prolinamide)-1-9-luteinizinghormone-releasingfactor(swine) |
Fertirelin is one of the most potent synthetic LHRH analogs inducing the release of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary gland. Fertirelin is used in veterinary medicine for the treatment of ovarian follicular cysts and for improving the conception rate. CAS Number (fertirelin acetate): 66002-66-2.
Fertirelin 是 GnRH 和 LH-RH 的类似物，可用于牛滤泡囊肿的研究。
Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.
曲普瑞林，去甘氨酸 10 促黄体生成素释放激素乙基酰胺是一种修饰促性腺激素释放肽，用于研究促黄体生成素释放激素类似物的稳定性和受体结合方向。其 C 端修饰增强基序分析的结构刚性。研究人员通过检测其折叠理解螺旋诱导元件。该分子为生殖肽构效探索提供支持。
Fertirelin Des-Gly¹⁰ LH-RH, Ethyl Amide is a modified gonadotropin-releasing peptide used to study stability and receptor-binding orientation within LH-RH analogs. Its C-terminal modification enhances structural rigidity for motif analysis. Researchers examine its folding to understand helix-inducing elements. The molecule contributes to structure-function exploration of reproductive peptides.
曲普瑞林是促性腺激素释放激素受体多肽激动剂，为促性腺激素释放激素衍生物，可结合表达人源受体的中国仓鼠卵巢细胞内促性腺激素释放激素受体，解离常数为 0.7 纳摩尔。体内实验中，每只奶牛使用 200 微克可提升血清促黄体生成素水平，促使卵泡囊肿发生黄体化。
Fertirelin is a peptide agonist of the gonadotropin-releasing hormone receptor (GnRHR) and a derivative of GnRH. It binds to GnRHR in CHO cells expressing the human receptor (K = 0.7 nM). In vivo , fertirelin (200 µg/animal) increases serum levels of luteinizing hormone and induces luteinization of follicular cysts in dairy cows.
| DOI | 名称 | |
|---|---|---|
| 10.1016/s0093-691x(03)00222-x | Effects of a GnRH agonist on oocyte number and maturation in mice superovulated with eCG and hCG | 下载 |
| 10.1248/cpb.33.4464 | Enzyme immunoassay for the determination of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in bovine plasma | 下载 |
| 10.1538/expanim.54.97 | Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice | 下载 |
| 10.1292/jvms.55.207 | Effect of fenprostalene 14 days after fertirelin treatment on intervals from treatment to conception in cows with follicular cysts diagnosed by milk progesterone test | 下载 |
