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<p>[SER140]-PLP(139-151) 是髓鞘蛋白脂质蛋白的多肽片段。</p> <p>[SER140]-PLP(139-151) is a fragment of myelin proteolipid protein.</p> <p>这种丝氨酸替代的PLP（139-151）在SJL小鼠中引起严重的急性实验性变态反应性脑脊髓炎。</p> <p>This serine substituted PLP (139-151) causes severe, acute experimental allergic encephalomyelitis in SJL mice.</p>  <p>Myelin PLP (139-151) is a basic protein that belongs to the family of oligodendrocyte-myelin glycoproteins. It has been shown to activate toll-like receptor, which is a pattern recognition receptor that recognizes invading pathogens and triggers an immune response. Myelin PLP (139-151) may play a role in the development of autoimmune diseases, as it has been found to be a target for autoantibodies. It has also been shown to have antioxidative properties, which may help prevent free radical damage in the brain and other tissues. The monoclonal antibody against this protein can be used for immunohistological analysis.</p> <p>Myelin PLP (139-151) acetate salt is a cyclic peptide that is derived from the sequence of human myelin basic protein and contains the sequence PLP (139-151). This peptide has shown to have antioxidative properties. It has been shown to have an inhibitory effect on the production of proinflammatory cytokines in experimental autoimmune encephalomyelitis (EAE), which is a model for multiple sclerosis. The peptide has also been shown to block signal pathways, such as toll-like receptor 4, and decrease Ca2+ overload. Clinical relevance remains unclear.</p> <p>PLP (139-151) is derived from Proteolipid Protein (PLP), an epitope of immunodominant encephalitogenic PLP and is involved in promoting encephalomyelitis.</p> <p>PLP (139-151) peptide is a fragment of myelin proteolipid protein (PLP or lipophilin), from amino acid residue 139 to 151 (HCLGKWLGHPDKF &ndash; CAS 131334-43-5 ). Myelin proteolipid protein is the major myelin protein from the central nervous system. PLP (139-151) peptide is commonly used to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. The PLP (139-151) peptide C140S is mutant of the wild-type version where the cystein is replaced by a serine to make the peptide more stable without impacting its antigenic activity.</p>