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Aviptadil 是一种血管活性肠多肽 (VIP) 类似物，具有强的血管舒张 (vasodilatory) 作用。Aviptadil 诱导肺血管扩张，抑制血管 SMCs 增殖、血小板聚集。Aviptadil 可用于肺纤维化、肺动脉高压 (PAH)、SARS-CoV-2 引起呼吸衰竭等的研究。

VIP是一种肽，是cAMP依赖性蛋白激酶（PKA）和磷脂酶C的激活剂。它还抑制肥大细胞释放组胺，刺激胃酸分泌，并引起血管舒张。VIP已被证明与许多蛋白质相互作用，包括离子通道和受体。该肽是神经肽Y受体（NPY-R）的配体，参与食欲，免疫反应和血压的调节。VIP可用作研究蛋白质相互作用的研究工具或药理学研究中的抑制剂。

VIP is a peptide that is an activator of cAMP-dependent protein kinase (PKA) and phospholipase C. It also inhibits the release of histamine from mast cells, stimulates gastric acid secretion, and causes vasodilation. VIP has been shown to interact with a number of proteins including ion channels and receptors. The peptide is a ligand for the neuropeptide Y receptor (NPY-R) and is involved in the regulation of appetite, immune responses, and blood pressure. VIP can be used as a research tool for studying protein interactions or as an inhibitor in pharmacological studies.

VIP是属于血管活性肠肽家族的多肽。VIP是腺苷酸环化酶的有效刺激剂，可增加细胞内cAMP水平并激活蛋白激酶a。VIP已被证明与离子通道受体（如烟碱乙酰胆碱受体）相互作用，并调节神经元细胞的膜电位。它还可以作为G蛋白偶联受体的配体，可用作针对VIP的免疫原或抗体。VIP已被证明具有多种药理作用，包括刺激细胞增殖和抑制细胞凋亡的能力。VIP也被证明是潜在TGF-β1的激活剂，可能在肿瘤抑制中发挥作用。

VIP is a polypeptide that belongs to the vasoactive intestinal peptide family. VIP is a potent stimulator of adenylate cyclase, which increases intracellular cAMP levels and activates protein kinase A. VIP has been shown to interact with ion channel receptors, such as the nicotinic acetylcholine receptor, and regulate membrane potentials in neuronal cells. It also functions as a ligand for G protein-coupled receptors and can be used as an immunogen or antibody against VIP. VIP has been shown to have a variety of pharmacological effects including the ability to stimulate cell proliferation and inhibit apoptosis. VIP has also been shown to function as an activator of latent TGF-β1, which may play a role in tumor suppression.

在中枢神经系统和胃肠道中合成的28个氨基酸的肽。它属于促胰液素-胰高血糖素CRF家族，广泛分布于中枢和周围神经系统。作为一种具有强大降压和血管舒张作用的神经递质和激素，该肽在一系列生物活动中发挥着广泛的作用，包括血管和支气管舒张，平滑肌松弛以及促胰液素的刺激。当与肾上腺药物酚妥拉明配对并注射时，这种肽有望为患有勃起功能障碍的患者提供新的有效解决方案。

A 28 amino acid peptide synthesized in the central nervous system and gastrointestinal tract. It belongs to the secretin glucagon-CRF family and is widely distributed in the central and peripheral nervous systems. In acting as both a neurotransmitter and hormone that has powerful hypotensive and vasodilatory effects, this peptide plays a wide role in a range of biological activities, including vaso- and bronchodilation, smooth muscle relaxation, and stimulation of secretin. When paired with the adrenegic drug phentolamine and injected, this peptide is expected to provide a new and effective solution for patients suffering from erectile dysfunction.

VIP（人、牛、猪、大鼠）代表多个物种中完整的天然 28 残基神经肽。螺旋 - 转角 - 螺旋拓扑结构支持 GPCR 结合和信号传导。物种间的结构变异提供比较见解。研究人员广泛将其用于内分泌和神经肽结构生物学。

VIP (human, bovine, porcine, rat) represents the full native 28-residue neuropeptide across multiple species. Helix-turn-helix topology supports GPCR binding and signaling. Structural variations among species provide comparative insights. Researchers use it extensively in endocrine and neuropeptide structural biology.

Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al[1][2].

[1]. Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)；https://clinicaltrials.gov/ct2/show/NCT04311697

[2]. Jian Hu, et al. Novel Targets of Drug Treatment for Pulmonary Hypertension. Am J Cardiovasc Drugs；https://pubmed.ncbi.nlm.nih.gov/26016608/

[3]. INVESTIGATOR’S BROCHURE Sponsor: NeuroRx, Inc；https://www.neurorxpharma.com/wp-content/uploads/2020/07/investigators-brochure-version-10.pdf