400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
来自酿酒酵母及其哺乳动物对应物 AMP 活化蛋白激酶 (AMPK) 的蔗糖非发酵蛋白激酶 (SNF1) 的特定底物。
编号：165136
CAS号：125911-68-4
单字母：H2N-HMRSAMSGLHLVKRR-OH
| 参考文献（References）: | 1. Davies, S.P., Carling, D., and Hardie, D.G. Tissue distribution of the AMP- activated protein kinase, and lack of activation by cyclic- AMP- dependent protein kinase, studied using a specific and sensitive peptide assay . Eur. J. Biochem. 186(1-2), 123-128 (1989) . <ALLPEPTIDE>2. Carling, D., Clarke, P.R., Zammit, V.A., et al . Purification and characterization of the AMP- activated protein kinase. Copurification of acetyl- CoA carboxylase kinase and 3- hydroxy- 3- methylglutaryl- CoA reductase kinase activities . Eur. J. Biochem. 186(1-2), 129-136 (1989) . 1. Davies, S.P., Carling, D., and Hardie, D.G. Tissue distribution of the AMP- activated protein kinase, and lack of activation by cyclic- AMP- dependent protein kinase, studied using a specific and sensitive peptide assay . Eur. J. Biochem. 186(1-2), 123-128 (1989) . <ALLPEPTIDE>2. Carling, D., Clarke, P.R., Zammit, V.A., et al . Purification and characterization of the AMP- activated protein kinase. Copurification of acetyl- CoA carboxylase kinase and 3- hydroxy- 3- methylglutaryl- CoA reductase kinase activities . Eur. J. Biochem. 186(1-2), 129-136 (1989) . 1. Davies, S.P., Carling, D., and Hardie, D.G. Tissue distribution of the AMP- activated protein kinase, and lack of activation by cyclic- AMP- dependent protein kinase, studied using a specific and sensitive peptide assay . Eur. J. Biochem. 186(1-2), 123-128 (1989) . <ALLPEPTIDE>2. Carling, D., Clarke, P.R., Zammit, V.A., et al . Purification and characterization of the AMP- activated protein kinase. Copurification of acetyl- CoA carboxylase kinase and 3- hydroxy- 3- methylglutaryl- CoA reductase kinase activities . Eur. J. Biochem. 186(1-2), 129-136 (1989) . |
| 溶解度: | DMF: 15 mg/ml DMSO: 15 mg/ml Ethanol: 1 mg/ml PBS (pH 7.2): 10 mg/ml |
| SMILES: | [H]N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)CCSC)=O)C)=O)=O)=O)CCSC)=O)CC2=CN=CN2 |
| InChI/InChI Code: | InChI=1S/C74H131N29O18S2/c1-38(2)27-51(66(115)100-53(30-43-32-84-37-90-43)67(116)99-52(28-39(3)4)68(117)103-57(40(5)6)70(119)97-45(15-10-11-21-75)61(110)95-46(16-12-22-85-72(77)78)62(111)98-50(71(120)121)18-14-24-87-74(81)82)92-56(106)33-88-60(109)54(34-104)101-65(114)48(19-25-122-8)93-58(107)41(7)91-69(118)55(35-105)102-63(112)47(17-13-23-86-73(79)80)96-64(113)49(20-26-123-9)94-59(108)44(76)29-42-31-83-36-89-42/h31-32,36-41,44-55,57,104-105H,10-30,33-35,75-76H2,1-9H3,(H,83,89)(H,84,90)(H,88,109)(H,91,118)(H,92,106)(H,93,107)(H,94,108)(H,95,110)(H,96,113)(H,97,119)(H,98,111)(H,99,116)(H,100,115)(H,101,114)(H,102,112)(H,103,117)(H,120,121)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t41-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,57-/m0/s1 |
| InChI Key: | YJAHUEAICBOBTC-CSVPVIMBSA-N |
| Formal Name: | L-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-L-arginine |
来自酿酒酵母及其哺乳动物对应物 AMP 活化蛋白激酶 (AMPK) 的蔗糖非发酵蛋白激酶 (SNF1) 的特定底物。
Specific substrate for the sucrose-non-fermenting protein kinase (SNF1) from Saccharomyces cerevisiae and its mammalian counterpart, AMP-activated protein kinase (AMPK).
SAMS 肽是基于乙酰辅酶 A 羧化酶磷酸化位点设计的腺苷酸活化蛋白激酶专用合成多肽底物，替换位点氨基酸消除蛋白激酶 A 结合位点，特异性优于天然蛋白，可被腺苷酸活化蛋白激酶快速磷酸化，便捷灵敏用于该激酶活性检测。
SAMS peptide is a synthetic peptide substrate for AMPK based on the sequence around Ser (which is phosphorylated exclusively by AMPK) on acetyl-CoA carboxylase. In this sequence, Ser (which is phosphorylated exclusively by PKA) is replaced by alanine to eliminate a neighboring binding site for PKA. This substitution yields a substrate more specific for AMPK than acetyl-CoA carboxylase itself. SAMS peptide is phosphorylated rapidly by AMPK, providing a convenient and sensitive tool for assaying AMPK activity.
SAMS 肽是基于乙酰辅酶 A 羧化酶磷酸化位点设计的腺苷酸活化蛋白激酶专用合成多肽底物，替换位点氨基酸消除蛋白激酶 A 结合位点，特异性优于天然蛋白，可被腺苷酸活化蛋白激酶快速磷酸化，便捷灵敏用于该激酶活性检测。
SAMS peptide is a synthetic peptide substrate for AMPK based on the sequence around Ser (which is phosphorylated exclusively by AMPK) on acetyl-CoA carboxylase. In this sequence, Ser (which is phosphorylated exclusively by PKA) is replaced by alanine to eliminate a neighboring binding site for PKA. This substitution yields a substrate more specific for AMPK than acetyl-CoA carboxylase itself. SAMS peptide is phosphorylated rapidly by AMPK, providing a convenient and sensitive tool for assaying AMPK activity.
SAMS 肽是基于乙酰辅酶 A 羧化酶磷酸化位点设计的腺苷酸活化蛋白激酶专用合成多肽底物，替换位点氨基酸消除蛋白激酶 A 结合位点，特异性优于天然蛋白，可被腺苷酸活化蛋白激酶快速磷酸化，便捷灵敏用于该激酶活性检测。
SAMS peptide is a synthetic peptide substrate for AMPK based on the sequence around Ser (which is phosphorylated exclusively by AMPK) on acetyl-CoA carboxylase. In this sequence, Ser (which is phosphorylated exclusively by PKA) is replaced by alanine to eliminate a neighboring binding site for PKA. This substitution yields a substrate more specific for AMPK than acetyl-CoA carboxylase itself. SAMS peptide is phosphorylated rapidly by AMPK, providing a convenient and sensitive tool for assaying AMPK activity.
| DOI | 名称 | |
|---|---|---|
| 10.1042/0264-6021:3550297 | Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK | 下载 |
