Anantin，GFIGWGNDIFGHYSGDF，从链霉菌中分离出来的环状肽的线性形式，作为 ANP 受体拮抗剂。
编号：152262
CAS号：348600-37-3
单字母：cyclo(GFIGWGND)-IFGHYSGDF(main chain(N-term)&side chain cyclo)
| 编号: | 152262 |
| 中文名称: | Anantin(linearsequence) |
| 英文名: | Anantin(linearsequence) |
| CAS号: | 348600-37-3 |
| 单字母: | cyclo(GFIGWGND)-IFGHYSGDF(main chain(N-term)&side chain cyclo) |
| 三字母: | cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe(main chain(N-term)&side chain cyclo) |
| 氨基酸个数: | 17 |
| 分子式: | C90H111N21O24 |
| 平均分子量: | 1870.97 |
| 精确分子量: | 1869.81 |
| 等电点(PI): | 7.55 |
| pH=7.0时的净电荷数: | 0.21 |
| 平均亲水性: | -0.99166666666667 |
| 疏水性值: | -0.05 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 6990 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 酰胺键环肽 |
Anantin, GFIGWGNDIFGHYSGDF, the linear form of the cyclic peptide isolated from streptomyces, acts as an ANP receptor antagonist.
多肽的内酰胺环肽的合成一般是利用Lys，Asp（Glu）的选择性保护，在固相上直接环化。BOC策略中可以采用BOC-Lys（Fmoc），BOC-Asp（OFm），FMOC策略中可以采用FMOC-Lys（Aloc），FMOC-Asp（Allyl）。对于首尾环肽，还可以先合成保护的多肽，然后在液相中环化生成目标多肽。
| DOI | 名称 | |
|---|---|---|
| 10.1016/s0006-291x(02)00803-3 | Regulation of the 26S proteasome activities by peptides mimicking cleavage products | 下载 |
| 10.1152/ajpgi.00427.2002 | Gastric atrial natriuretic peptide regulates endocrine secretion in antrum and fundus of human and rat stomach | 下载 |
| 10.1124/jpet.103.060913 | Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells | 下载 |
| 10.7164/antibiotics.44.172 | Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments | 下载 |
| 10.7164/antibiotics.44.164 | Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). I. Producing organism, fermentation, isolation and biological activity | 下载 |
| 10.1007/s00424-014-1557-4 | Role of atrial natriuretic peptide in mediating the blood pressure-independent natriuresis elicited by systemic inhibition of nitric oxide | 下载 |
