400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
The copper-complexing dipeptide glycyl-L-histidine also forms complexes with Au (III) and Pd (II).
编号：160306
CAS号：2489-13-6/3486-76-8/2489-13-6
单字母：H2N-GH-OH
| 编号: | 160306 |
| 中文名称: | 二肽GLY-His |
| 中文同义词: | 甘氨酰-组氨酸 |
| 英文名: | Gly-Hishydrochloride |
| CAS号: | 2489-13-6/3486-76-8/2489-13-6 |
| 单字母: | H2N-GH-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Gly甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -HisL-组氨酸：histidine。系统命名为(2S)-氨基-3-(4-咪唑基)丙酸。其侧链带有弱碱性的咪唑基，为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号：H，His。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C8H12N4O3 |
| 平均分子量: | 212.21 |
| 精确分子量: | 212.09 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.21 |
| 平均亲水性: | -0.5 |
| 疏水性值: | -1.8 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 657.9±55.0°Cat760mmHg |
| 熔点: | 178°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00167467 |
| 参考文献（References）: | <ALLPEPTIDE>Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.<ALLPEPTIDE>Biljana D Glisi?, et al. A comparative study of complex formation in the reactions of gold(III) with Gly-Gly, Gly-L-Ala and Gly-L-His dipeptides. Bioorg Chem. 2010 Aug;38(4):144-8.<ALLPEPTIDE>C E S?nger-van de Griend, et al. Enantiomeric separation of glycyl dipeptides by capillary electrophoresis with cyclodextrins as chiral selectors. Electrophoresis. 1999 Nov;20(17):3417-24.<ALLPEPTIDE>Christina Gatschelhofer, et al. Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP). J Biochem Biophys Methods. 2006 Nov 30;69(1-2):67-77.<ALLPEPTIDE>Ekaterina S Ryabova, et al. A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin. J Inorg Biochem. 2005 Mar;99(3):852-63. <ALLPEPTIDE>Biljana D Glisi?, et al. A comparative study of complex formation in the reactions of gold(III) with Gly-Gly, Gly-L-Ala and Gly-L-His dipeptides. Bioorg Chem. 2010 Aug;38(4):144-8.<ALLPEPTIDE>E Matczak-Jon, et al. Interaction of Pd(II) glycyl--L-histidine complex with cytidine and GMP. Proton and carbon-13 nmr studies. J Inorg Biochem. 1980 Apr;12(2):143-56.<ALLPEPTIDE>Ekaterina S Ryabova, et al. A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin. J Inorg Biochem. 2005 Mar;99(3):852-63.<ALLPEPTIDE>Flora Carrera, et al. Nature of metal binding sites in Cu(II) complexes with histidine and related N-coordinating ligands, as studied by EXAFS. Inorg Chem. 2004 Oct 18;43(21):6674-83.<ALLPEPTIDE>Giampiero De Sanctis, et al. pH-dependent redox and CO binding properties of chelated protoheme-L-histidine and protoheme-glycyl-L-histidine complexes. J Biol Inorg Chem. 2006 Mar;11(2):153-67. |
| TPSA: | 121.1 |
| LogP : | -1.0979 |
| H_Acceptors: | 4.0 |
| H_Donors: | 4.0 |
| Rotatable_Bonds: | 5.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | C(C1=CNC=N1)[C@@H](C(=O)O)NC(=O)CN.Cl |
The copper-complexing dipeptide glycyl-L-histidine also forms complexes with Au (III) and Pd (II).
H‑Gly‑His‑OH 是一种极简二肽，用于研究金属结合与质子化状态行为。组氨酸残基有助于配位化学与催化建模。溶解性与构象自由度支持动力学实验。研究应用包括短肽折叠研究与生化相互作用分析。
H-Gly-His-OH provides a minimalistic dipeptide useful for studying metal-binding and protonation-state behavior. The histidine residue contributes to coordination chemistry and catalytic modeling. Solubility and conformational freedom support kinetic assays. Research applications include short-peptide folding studies and biochemical interaction analysis.
| DOI | 名称 | |
|---|---|---|
| 10.1080/09687860500093248 | Substrate preference is altered by mutations in the fifth transmembrane domain of Ptr2p, the di/tri-peptide transporter of Saccharomyces cerevisiae | 下载 |
| 10.1002/bit.24507 | Utilization of tyrosine- and histidine-containing dipeptides to enhance productivity and culture viability | 下载 |
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