400-998-5282
专注多肽 服务科研

烟碱型乙酰胆碱受体中保守序列的这个片段激活 T 辅助淋巴细胞并诱导自身抗体的产生,从而导致实验性自身免疫性重症肌无力的电生理学迹象。EIIVTHFPFDEQNCSMK 可用于开发基于肽的重症肌无力抗原特异性免疫疗法。
编号:151737
CAS号:194737-11-6
单字母:H2N-EIIVTHFPFDEQNCSMK-OH
This fragment of a conserved sequence in nicotinic acetylcholine receptor activates T helper lymphocytes and induces the production of autoantibodies that cause electrophysiologic signs of experimental autoimmune myasthenia gravis. EIIVTHFPFDEQNCSMK may be useful in the development of a peptide-based antigen-specific immunotherapy of myasthenia gravis.
ReversalH.Yoshikawa et al., J. Immunol., 159, 1570(1997) : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9233656




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