400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 514779 |
| 中文名称: | Boc-L-天冬氨酸4-苄酯 |
| 英文名: | (2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoicacid |
| 英文同义词: | (2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoicacid、Boc-L-Asp(OBn)-OH |
| CAS号: | 7536-58-5 |
| 单字母: | Boc-D(OBzl)-OH |
| 三字母: | Boc N端Boc保护；叔丁氧羰基或叔丁氧羰基（Boc）是胺的保护基团。Boc基团可用强酸去除，如用三氟乙酸在二氯甲烷中去除，或用HCl在甲醇中去除。 -Asp(OBzl)侧链OBzl保护的天冬氨酸 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 1 |
| 分子式: | C16H21O6N1 |
| 平均分子量: | 323.34 |
| 精确分子量: | 323.14 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | - |
| 疏水性值: | - |
| 沸点: | 508.1°Cat760mmHg |
| 熔点: | 98-102°C |
| 闪点: | 261.1°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95% 或98%可选 |
| 盐体系: | 若定制，可选TFA盐、醋酸盐、盐酸盐和柠檬酸盐等 |
| 生成周期: | 现货或定制2-3周，请咨询销售人员 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | Boc保护氨基酸 OBzl保护氨基酸 天冬氨酸类 |
| MDL号: | MFCD00065564 |
| 参考文献（References）: | <ALLPEPTIDE>Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.<ALLPEPTIDE>J J McTigue, et al. Vitamin K-dependent carboxylase. Carboxylation of aspartyl residues to beta-carboxyaspartyl residues in synthetic substrates. J Biol Chem. 1984 Apr 10;259(7):4272-8.<ALLPEPTIDE>S E Hamilton, et al. Vitamin K1 dependent carboxylase: beta-carboxylation of t-butyloxycarbonylaspartic acid alpha-benzyl ester. Biochem Biophys Res Commun. 1982 Jul 16;107(1):246-9. |
| TPSA: | 101.93 |
| LogP : | 2.0978 |
| H_Acceptors: | 5.0 |
| H_Donors: | 2.0 |
| Rotatable_Bonds: | 6.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | O=C(OCC1=CC=CC=C1)C[C@H](NC(OC(C)(C)C)=O)C(O)=O |
Boc-Asp(OBzl)-OH is a cyclic peptide analog with an amino acid sequence homologous to the natural substrate of soybean trypsin. It has been shown to inhibit thrombin by intramolecular hydrogen bonding. Boc-Asp(OBzl)-OH has also been used as a prodrug for the synthesis of other analogs, such as Asp(OBzl)-Bz-NH2, which inhibits human immunodeficiency virus type 1 (HIV-1) protease. This inhibitor has been found to be effective in vitro and in vivo against HIV-1 strains that are resistant to other protease inhibitors, such as saquinavir, indinavir, and ritonavir.
