A high level of inhibition of virus replication was obtained with this peptide, which resembles a region of a viral polypeptide.
编号:190051
CAS号:75539-79-6
单字母:Z-fFG-OH
编号: | 190051 |
中文名称: | 三肽Cbz-DPhe-Phe-GLY |
英文名: | Z-D-Phe-Phe-Gly-OH |
英文同义词: | Fusion Inhibitory Peptide, FIP, Virus Replication Inhibitory Peptide |
CAS号: | 75539-79-6 |
单字母: | Z-fFG-OH |
三字母: | Cbz N端Cbz保护 -DPheD型笨丙氨酸 -Phe苯丙氨酸 -Gly甘氨酸 -OHC端羧基 |
氨基酸个数: | 3 |
分子式: | C28H29O6N3 |
平均分子量: | 503.55 |
精确分子量: | 503.21 |
等电点(PI): | - |
pH=7.0时的净电荷数: | - |
平均亲水性: | -2.5 |
疏水性值: | 1.73 |
外观与性状: | 白色粉末状固体 |
消光系数: | - |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
纯度: | 95%、98% |
盐体系: | 可选TFA、HAc、HCl或其它 |
储存条件: | 负80℃至负20℃ |
标签: | D型氨基酸肽 CBZ修饰肽 三肽 病毒学 |
A high level of inhibition of virus replication was obtained with this peptide, which resembles a region of a viral polypeptide.
很多蛋白在细胞中非常容易被降解,或被标记,进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
DOI | 名称 | |
---|---|---|
10.1128/jvi.76.15.7460-7467.2002 | Efficiency of measles virus entry and dissemination through different receptors | 下载 |
10.1128/jvi.77.7.4181-4190.2003 | Mutations in the putative HR-C region of the measles virus F2 glycoprotein modulate syncytium formation | 下载 |
10.1128/JVI.80.7.3477-3486.2006 | Measles virus targets DC-SIGN to enhance dendritic cell infection | 下载 |
10.1111/j.1462-5822.2006.00752.x | Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation | 下载 |
10.1016/j.virol.2007.02.033 | Neurokinin-1 enables measles virus trans-synaptic spread in neurons | 下载 |
10.3748/wjg.v13.i22.3063 | In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines | 下载 |
10.1371/journal.ppat.1000049 | DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes | 下载 |
10.1021/bi801513p | Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance | 下载 |
10.1128/AAC.00503-09 | Target analysis of the experimental measles therapeutic AS-136A | 下载 |
10.1128/JVI.01195-09 | Probing the spatial organization of measles virus fusion complexes | 下载 |
10.1016/j.vaccine.2011.04.079 | Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay | 下载 |
10.1002/eji.201041305 | Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross-presentation | 下载 |
10.1089/hum.2011.146 | Retargeting vesicular stomatitis virus using measles virus envelope glycoproteins | 下载 |
10.1128/JVI.01945-13 | A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion | 下载 |
10.1007/BF01114759 | Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase | 下载 |
10.1016/0042-6822(80)90168-3 | Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides | 下载 |
10.1038/mt.2009.39 | Intravascularly administered RGD-displaying measles viruses bind to and infect neovessel endothelial cells in vivo | 下载 |
10.1016/j.exphem.2013.01.010 | Enhancing cytokine-induced killer cell therapy of multiple myeloma | 下载 |