400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
Aspartame Impurity B, saponofication product of aspartame.
编号：197925
CAS号：13433-09-5
单字母：H2N-DF-OH
| 编号: | 197925 |
| 中文名称: | 二肽Asp-Phe |
| 英文名: | Asp-Phe |
| CAS号: | 13433-09-5 |
| 单字母: | H2N-DF-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -AspL-天冬氨酸：aspartic acid。系统命名为(2S)-氨基-丁二酸。是编码氨基酸，又是神经递质。符号：D，Asp。D-天冬氨酸存在于多种细菌的细胞壁和短杆菌肽A中。 -PheL-苯丙氨酸：phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：F，Phe。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C13H16N2O5 |
| 平均分子量: | 280.28 |
| 精确分子量: | 280.11 |
| 等电点(PI): | 6.26 |
| pH=7.0时的净电荷数: | -0.02 |
| 平均亲水性: | 0.25 |
| 疏水性值: | -0.35 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| 参考文献（References）: | 1. Grobelny, D., and Galardy, R.E. A metabolite of aspartame inhibits angiotensin converting enzyme . Biochem. Biophys. Res. Commun. 128(2), 960-964 (1985) . <ALLPEPTIDE>2. Tobey, N.A., and Heizer, W.D. Intestinal hydrolysis of aspartylphenylalanine-- the metabolic product of aspartame . Gastroenterology 91(4), 931-937 (1986) . <ALLPEPTIDE>3. Stolzenberg-Solomon, R.Z., Derkach, A., Moore, S., et al . Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study . Gut 69(11), 2008-2015 (2020) . |
| 溶解度: | DMSO: 5 mg/ml DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml |
| SMILES: | OC(C[C@H](N)C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)=O |
| InChI/InChI Code: | InChI=1S/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/t9-,10-/m0/s1 |
| InChI Key: | YZQCXOFQZKCETR-UWVGGRQHSA-N |
| Formal Name: | L-α-aspartyl-L-phenylalanine |
Aspartame Impurity B, saponofication product of aspartame.
H-Asp-Phe-OH is a diagnostic agent that contains the amino acid aspartame and a hydroxyl group. It is hydrolyzed in the body to form aspartic acid, phenylalanine, and methanol. The methyl ester of H-Asp-Phe-OH is hydrochloride. This compound has been used to study locomotor activity in mice and rats. Aspartame has also been shown to be an inhibitor of certain enzymes, such as fatty acid synthase, which is associated with human pathogens. The lc-ms/ms method has been used to detect H-Asp-Phe-OH metabolites in human serum samples. In addition, this compound can be used for the diagnosis of diseases such as diabetes mellitus type 2 and Alzheimer’s disease by measuring uptake into cells at enzyme activities.
L - 天冬氨酰 - L - 苯丙氨酸是血管紧张素转换酶二肽抑制剂，也是无糖甜味剂阿斯巴甜的体内代谢产物，由肠道酯酶分解阿斯巴甜生成。该物质抑制兔源血管紧张素转换酶的解离常数为 11 微摩尔，其血清含量与胰腺导管腺癌发病呈正相关。
L-Aspartyl-L-phenylalanine is a dipeptide inhibitor of angiotensin-converting enzyme (ACE) and a metabolite of the synthetic non-caloric sweetener aspartame (Item No. 26089 ). It is formed from aspartame by intestinal intracellular esterases. L-Aspartyl-L-phenylalanine inhibits ACE with a K value of 11 µM for the rabbit enzyme. Serum levels of L-aspartyl-L-phenylalanine are positively associated with pancreatic ductal adenocarcinoma.
| DOI | 名称 | |
|---|---|---|
| 10.1021/bi050008r | Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli | 下载 |
| 10.1021/bi901397h | The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity | 下载 |
| 10.1093/jn/119.5.713 | Identification of N-beta-L-aspartyl-L-phenylalanine as a normal constituent of human plasma and urine | 下载 |
| 10.1021/ja01038a046 | Structure-taste relationships of some dipeptides | 下载 |
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