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二肽 Arg-Phe 模拟 FMRF 酰胺的血液动力学效应。通过交感神经系统的中枢刺激,这两种肽都增加了麻醉大鼠的血压和心率,RF 的效力大约是其 4 倍。
编号:192466
CAS号:2047-13-4/102029-92-5
单字母:H2N-RF-OH
编号: | 192466 |
中文名称: | 二肽Arg-Phe |
英文名: | Arg-Phe |
CAS号: | 2047-13-4,TFA盐 102029-92-5,醋酸盐 |
单字母: | H2N-RF-OH |
三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。 -ArgL-精氨酸:arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷,为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号:R,Arg。 -PheL-苯丙氨酸:phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号:F,Phe。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
氨基酸个数: | 2 |
分子式: | C15H23N5O3 |
平均分子量: | 321.37 |
精确分子量: | 321.18 |
等电点(PI): | - |
pH=7.0时的净电荷数: | 1.97 |
平均亲水性: | 0.25 |
疏水性值: | -0.85 |
外观与性状: | 白色粉末状固体 |
消光系数: | - |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
纯度: | 95%、98% |
盐体系: | 可选TFA、HAc、HCl或其它 |
生成周期: | 2-3周 |
储存条件: | 负80℃至负20℃ |
标签: | 600+种二肽(Dipeptide)现货 |
The dipeptide Arg-Phe mimics the haemodynamic effects of FMRF amide. Both peptides increased blood pressure and heart rate in anaesthesized rats by central stimulation of the sympathetic nervous system, RF being approximately 4 fold more potent.
"Peptide H-RF-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-RF-OH include the following: Bitter-RF: a random forest machine model for recognizing bitter peptides YF Zhang, YH Wang, ZF Gu, XR Pan, J Li - Frontiers in , 2023 - frontiersin.orghttps://www.frontiersin.org/articles/10.3389/fmed.2023.1052923/full Conformational features of a synthetic cyclic peptide corresponding to the complete V3 loop of the RF HIV-1 strain in water and water/trifluoroethanol solutions WF Vranken , M Budesinsky, JC Martins - European journal of , 1996 - Wiley Online Libraryhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-1033.1996.00100.x Influence of charge distribution on the discrepant MS/MS fragmentation of the native and oxidized FMRF: evidence for the mobile proton model W Zong, R Liu , F Sun, P Zhang - Journal of Peptide , 2010 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.1286 Repetitive Gly-Leu-Lys-Gly-Glu-Asn-Arg-Gly-Asp peptide derived from collagen and fibronectin for improving cell-scaffold interaction P Chaisri, A Chingsungnoen , S Siri - Applied biochemistry and , 2015 - Springerhttps://link.springer.com/article/10.1007/s12010-014-1388-y CPPred-RF: a sequence-based predictor for identifying cell-penetrating peptides and their uptake efficiency L Wei , PW Xing , R Su, G Shi, ZS Ma - Journal of Proteome , 2017 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.7b00019 Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone). JS Kizer, WH Busby Jr, C Cottle - Proceedings of the , 1984 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.81.10.3228 Amyloidogenic model peptides as catalysts for stereoselective aldol reactions JNBD Pelin , BB Gerbelli , BM Soares - Catalysis Science & , 2019 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2019/cy/c9cy00790c A role for the 2 OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue JJ Shaw , S Trobro, SL He, J acaâ\x80Šqvist , R Green - Chemistry & biology, 2012 - cell.comhttps://www.cell.com/ccbio/pdf/S1074-5521(12)00218-9.pdf THE CHEMICAL STRUCTURE OF THE TUBERCULIN ACTIVE PEPTIDE I. ISOLATION OF beta-ALANINE AS THE N-TERMINAL RESIDUE OF THE ACTIVE PEPTIDE I KASUYA, A HAGITANI - The Journal of Biochemistry, 1955 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/biochemistry1922/42/6/42_6_805/_article/-char/ja/ Structure-based prediction of protein-peptide binding regions using Random Forest G Taherzadeh , Y Zhou , AWC Liew , Y Yang - Bioinformatics, 2018 - academic.oup.comhttps://academic.oup.com/bioinformatics/article-abstract/34/3/477/4237510 Rheumatoid-factor-reactive sites on CH3 established by overlapping 7-mer peptide epitope analysis C Peterson, CC Malone, RC Williams Jr - Molecular immunology, 1995 - Elsevierhttps://www.sciencedirect.com/science/article/pii/016158909400122H AIPpred: sequence-based prediction of anti-inflammatory peptides using random forest B Manavalan , TH Shin , MO Kim , G Lee - Frontiers in pharmacology, 2018 - frontiersin.orghttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00276/full"
DOI | 名称 | |
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10.1016/s0006-291x(05)81237-9 | FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system | 下载 |
10.1016/j.jasms.2005.02.008 | Stereoselective discrimination and quantification of arginine and N-blocked arginine enantiomers by formation and dissociation of calcium-mediated diastereomeric trimer complexes with a chiral reference compound using electrospray ionization-ion trap tandem mass spectrometry | 下载 |
10.1016/0014-5793(91)81434-a | On the substrate specificity of nitric oxide synthase | 下载 |