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该纤维蛋白原序列与 ICAM 1 结合并介导白细胞-内皮细胞相互作用。它可能导致纤维蛋白原依赖性炎症。这为在体内高度选择性地抑制纤维蛋白原依赖性细胞炎症反应提供了靶标。
编号:141883
CAS号:160927-63-9
单字母:H2N-NNQKIVNLKEKVAQLEA-OH
This fibrinogen sequence binds to ICAM 1 and mediates leukocyte-endothelium interaction. It potentially contributes to fibrinogen dependent inflammation. This provides a target for highly selective inhibition of fibrinogen dependent cellular inflammatory responses in vivo.
| DOI | 名称 | |
|---|---|---|
| 10.1074/jbc.270.2.696 | Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction | 下载 |
| 10.1073/pnas.92.5.1505 | Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition | 下载 |





