细胞可渗透的、不可逆的 caspase-1 (ICE) 抑制剂。N.Rouquet 等。表明Ac-YVAD-CMK是一种有效的治疗小鼠体内肝细胞凋亡的药物。
编号：169055
CAS号：178603-78-6
单字母：Ac-YVAD-CMK
| 编号: | 169055 |
| 中文名称: | Caspase 1 Inhibitor II |
| 英文名: | Caspase 1 Inhibitor II |
| CAS号: | 178603-78-6 |
| 单字母: | Ac-YVAD-CMK |
| 三字母: | Ac N端乙酰化封端 -Tyr酪氨酸 -Val缬氨酸 -Ala丙氨酸 -Asp天冬氨酸 -CMKC端氯甲基酮修饰 |
| 氨基酸个数: | 4 |
| 分子式: | C24H33O9N4l1 |
| 平均分子量: | 521.54 |
| 精确分子量: | 521.22 |
| 等电点(PI): | 7.01 |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -0.6 |
| 疏水性值: | 0.4 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CMK(氯甲基酮)修饰 |
Cell-permeable, irreversible inhibitor of caspase-1 (ICE). N.Rouquet et al. showed that Ac-YVAD-CMK is a potent therapeutic agent against in vivo liver apoptosis in mice.
| DOI | 名称 | |
|---|---|---|
| 10.1164/ajrccm.159.4.9712012 | LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock | 下载 |
| 10.1038/sj.bjp.0703629 | Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses | 下载 |
| 10.1107/s0907444900009884 | Crystallization and preliminary X-ray diffraction analysis of a recombinant cysteine-free mutant of crmA | 下载 |
| 10.1111/j.1349-7006.2003.tb01358.x | Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells | 下载 |
| 10.1038/sj.cdd.4401247 | Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity | 下载 |
| 10.1254/jphs.fpj03102x | Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species | 下载 |
| 10.1248/bpb.27.1527 | Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929 | 下载 |
| 10.1080/09674845.2004.11732672 | Induction of apoptosis in myeloid progenitors by granulocyte-macrophage colony-stimulating factor | 下载 |
| 10.1016/j.cell.2006.07.033 | Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival | 下载 |
| 10.1016/j.surneu.2007.03.041 | Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats | 下载 |
| 10.1016/j.cellbi.2008.08.021 | Cadmium toxicity in cultured tomato cells--role of ethylene, proteases and oxidative stress in cell death signaling | 下载 |
| 10.1002/eji.201142268 | IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation | 下载 |
| 10.1016/j.brainres.2014.04.019 | Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons | 下载 |
| 10.1371/journal.ppat.1004599 | Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection | 下载 |
| 10.1046/j.1365-2567.2000.00921.x | CD95 ligand expression as a mechanism of immune escape in breast cancer | 下载 |
| 10.1046/j.1462-5822.2001.00162.x | Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1 | 下载 |
| 10.1248/bpb.26.1543 | Intracellular regulation of evodiamine-induced A375-S2 cell death | 下载 |
