154445-77-9_Fmoc-Arg(Pbf)-OH、Fmoc-Pbf-精氨酸_Fmoc-Arg(Pbf)-OH_Fmoc-R(Pbf)-OH_Fmoc保护氨基酸_ 精氨酸类

Fmoc-Arg(Pbf)-OH、Fmoc-Pbf-精氨酸
Fmoc固相多肽合成中Fmoc保护的精氨酸Arg

编号：160451

CAS号：154445-77-9

单字母：Fmoc-R(Pbf)-OH

编号:	160451
中文名称:	Fmoc-Arg(Pbf)-OH、Fmoc-Pbf-精氨酸
中文同义词:	Fmoc-Pbf-精氨酸
英文名:	Fmoc-Arg(Pbf)-COOH
英文同义词:	Fmoc-Arg(Pbf)-OH、
CAS号:	154445-77-9
单字母:	Fmoc-R(Pbf)-OH
三字母:	Fmoc N端Fmoc保护，9-芴甲氧羰基（Fmoc）是伯胺和仲胺的保护基团。在固相肽合成（SPPS）中，它是氨基酸主链的常用保护基，因为它可以很容易地用哌啶去除，而不会干扰树脂和肽之间的酸不稳定连接体。 -Arg(Pbf) 侧链Pbf保护的精氨酸 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	1
分子式:	C₃₄H₄₀O₇N₄S₁
平均分子量:	648.77
精确分子量:	648.26
等电点(PI):	-
pH=7.0时的净电荷数:	-
平均亲水性:	-
疏水性值:	-
熔点:	132°C
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
纯度:	95%、98%
盐体系:	可选TFA、HAc、HCl或其它
规格:	25g,100g
生成周期:	2-3周
储存条件:	负80℃至负20℃
标签:	Fmoc保护氨基酸 精氨酸类

MDL号:	MFCD00235804
参考文献（References）:	<ALLPEPTIDE>Beatriz G, et al. Successful development of a method for the incorporation of Fmoc-Arg (Pbf)-OH in solid-phase peptide synthesis using N-butylpyrrolidinone (NBP) as solvent. Green Chemistry, 2020, 22(10): 3162-3169.<ALLPEPTIDE>Felista Tansi, et al. Internalization of Near-Infrared Fluorescently Labeled Activatable Cell-Penetrating Peptide and of Proteins into Human Fibrosarcoma Cell Line HT-1080. J Cell Biochem. 2015 Jul;116(7):1222-31.<ALLPEPTIDE>Mija Ahn, et al. A new class of peptidomimetics targeting the polo-box domain of Polo-like kinase 1. J Med Chem. 2015 Jan 8;58(1):294-304.<ALLPEPTIDE>Paul W R Harris, et al. Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines. Biopolymers. 2015 Mar;104(2):116-27.<ALLPEPTIDE>Soo Min Cho, et al. Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model. Sci Rep. 2014 Oct 27:4:6777.
TPSA:	166.91
LogP :	4.90013
H_Acceptors:	7.0
H_Donors:	5.0
Rotatable_Bonds:	10.0
警示词:	Warning
危险申明:	H302-H315-H319-H335
警告申明:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
GHS编码:	GHS07
SMILES:	N=C(NS(=O)(C1=C(C)C(C)=C(OC(C)(C)C2)C2=C1C)=O)NCCC[C@@H](C(O)=O)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O

Fmoc固相多肽合成中Fmoc保护的精氨酸Arg

Fmoc-Arg(Pbf)-OH is an amido-resin that is used in the industrial preparation of polyamides and as a reactive component for the synthesis of various peptide or protein drugs. The polymerisation reaction leads to the formation of a linear chain with a high molecular weight and low viscosity. Fmoc-Arg(Pbf)-OH has been used as an envisaged component for the synthesis of acetylcholine, messenger RNA, and nicotinic acetylcholine receptor. Trifluoroacetic acid is commonly used as a solvent in this process.
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