Cyclo(His-Gly) inhibited the growth of MCF-7 cancer cells in vitro and showed antithrombotic effects. Cyclo-(His-Gly), which is related to anorexigenic peptide, was shown to inhibit release of catecholamine and norepinephrine in vitro significantly. The d
编号：180802
CAS号：15266-88-3
单字母：cyclo(GH)(main chain cyclo)
| 编号: | 180802 |
| 中文名称: | 环二肽cyclo(Gly-His) |
| 英文名: | c(Gly-His) |
| 英文同义词: | c(His-Gly)、cyclo(His-Gly) |
| CAS号: | 15266-88-3 |
| 单字母: | cyclo(GH)(main chain cyclo) |
| 三字母: | cyclo(Gly-His)(main chain cyclo) |
| 氨基酸个数: | 2 |
| 分子式: | C8H10N4O2 |
| 平均分子量: | 194.19 |
| 精确分子量: | 194.08 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.21 |
| 平均亲水性: | -0.5 |
| 疏水性值: | -1.8 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 修饰类型: | 酰胺键成环 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 环二肽 现货多肽 |
Cyclo(His-Gly) inhibited the growth of MCF-7 cancer cells in vitro and showed antithrombotic effects. Cyclo-(His-Gly), which is related to anorexigenic peptide, was shown to inhibit release of catecholamine and norepinephrine in vitro significantly. The diketopiperazine could play a role in the hypothalamic modulation of appetite suppressant circuitry.
环二肽又叫2,5-二酮哌嗪的衍生物,作为环肽成员中最小的一类环肽，专肽生物有部分环二肽的现货，也可以根据实验需求，定制含D型与L型，S与R构型的氨基酸。
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.peptides.2006.04.023 | The biological activity of the histidine-containing diketopiperazines cyclo(His-Ala) and cyclo(His-Gly) | 下载 |
| 10.1016/s1734-1140(13)71063-6 | Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro | 下载 |
