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凝血酶受体激动剂 TRAP-7,SFLLRNP,对应于凝血酶受体的 42-48 位残基。在某些 T 细胞系中,TRAP-7 在诱导 Ca²⁺ 动员和蛋白激酶 C 活化方面与凝血酶一样有效。
编号:151146
CAS号:145229-76-1
单字母:H2N-SFLLRNP-OH
| 参考文献(References): | B.Mari et al., J. Biol. Chem., 269, 8517 (1994) Molloy, C. et al. J. Clin. Invest. 97, 1173 (1996) Ishida, A. et al. FEBS Lett. 427, 155 (1998) Ishida, A. and H. Fujisawa, J. Biol. Chem. 270, 2163 (1995) |
凝血酶受体激动剂TRAP-7,SFLLRNP,对应于凝血酶受体的残基42-48。TRAP-7在诱导Ca²方面与凝血酶一样有效⁺ 一些T细胞系中的动员和蛋白激酶C活化。
The thrombin receptor agonist TRAP-7, SFLLRNP, corresponds to residues 42-48 of the thrombin receptor. TRAP-7 is as effective as thrombin in inducing Ca²⁺ mobilization and protein kinase C activation in some T cell lines.
H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-OH是一种具有显着细胞毒性的生物相容性聚合物。它是一种治疗传染病、癌症和大脑功能的药物。该聚合物已被证明在动脉粥样硬化的实验模型中是有效的,并且在低剂量组中也诱导神经元死亡。H-Ser-Phe-Leu-Leu-Arg-Asn Pro-OH是一种信号肽,参与细胞增殖,凋亡和血管生成等生理作用。
H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-OH is a biocompatible polymer that has significant cytotoxicity. It is a pharmacological treatment for infectious diseases, cancer, and brain functions. This polymer has been shown to be effective in the experimental model of atherosclerosis and also induces neuronal death in the low dose group. H-Ser-Phe-Leu-Leu-Arg-Asn Pro OH is a signal peptide that is involved in physiological effects such as cell proliferation, apoptosis, and angiogenesis.
TRAP-7 是一种凝血酶受体激活肽,用于研究蛋白酶介导的信号传导和受体切割机制。其序列支持受体激活所需最小基序的详细分析。研究人员用它探索肽与蛋白水解结构域之间的动态相互作用。该分子对 GPCR 激活通路建模有重要贡献。
TRAP-7 is a thrombin receptor-activating peptide used to study protease-mediated signaling and receptor cleavage mechanisms. Its sequence supports detailed analysis of minimal motifs required for receptor activation. Researchers employ it to explore dynamic interactions between peptides and proteolytic domains. The molecule contributes to modeling GPCR activation pathways.
人凝血酶受体(42‑48)激动剂包含经典 SFLLRN 核心基序,可激活蛋白酶激活受体 1。序列结构支持受体结合所需的延伸构象。动态柔性有助于对接分析。该多肽常用于凝血酶受体信号实验。
Thrombin Receptor (42–48) Agonist, human, contains the canonical SFLLRN core motif enabling PAR-1 activation. Sequence structure supports extended conformations for receptor engagement. Dynamic flexibility facilitates docking analysis. The peptide is commonly used in thrombin-receptor signaling assays.
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