甲状旁腺激素（1-34）（牛）是一种甲状旁腺激素（PTH）受体激动剂。它能提高幼鼠血清中的钙和无机磷酸盐水平。
编号：140300
CAS号：12583-68-5
单字母：H2N-AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF-OH
| 编号: | 140300 |
| 中文名称: | Parathyroid Hormone(1-34), bovine |
| 英文名: | Parathyroid Hormone(1-34), bovine |
| 英文同义词: | Parathyroid hormone (1-34) (bovine) |
| CAS号: | 12583-68-5 |
| 单字母: | H2N-AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF-OH |
| 三字母: | H2N N端氨基 -Ala丙氨酸 -Val缬氨酸 -Ser丝氨酸 -Glu谷氨酸 -Ile异亮氨酸 -Gln谷氨酰胺 -Phe苯丙氨酸 -Met甲硫氨酸 -His组氨酸 -Asn天冬酰胺 -Leu亮氨酸 -Gly甘氨酸 -Lys赖氨酸 -His组氨酸 -Leu亮氨酸 -Ser丝氨酸 -Ser丝氨酸 -Met甲硫氨酸 -Glu谷氨酸 -Arg精氨酸 -Val缬氨酸 -Glu谷氨酸 -Trp色氨酸 -Leu亮氨酸 -Arg精氨酸 -Lys赖氨酸 -Lys赖氨酸 -Leu亮氨酸 -Gln谷氨酰胺 -Asp天冬氨酸 -Val缬氨酸 -His组氨酸 -Asn天冬酰胺 -Phe苯丙氨酸 -OHC端羧基 |
| 氨基酸个数: | 34 |
| 分子式: | C183H288N54O50S2 |
| 平均分子量: | 4108.71 |
| 精确分子量: | 4106.11 |
| 等电点(PI): | 10.5 |
| pH=7.0时的净电荷数: | 2.69 |
| 平均亲水性: | 0.066666666666667 |
| 疏水性值: | -0.54 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 5500 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 其它激动剂多肽(Agonist Peptide) 甲状旁腺(激)素及类似物 |
甲状旁腺激素（1-34）（牛）是一种甲状旁腺激素（PTH）受体激动剂。它能提高幼鼠血清中的钙和无机磷酸盐水平。甲状旁腺激素（PTH）是细胞外液中钙和磷浓度最重要的内分泌调节因子，由甲状旁腺的主要细胞分泌，是一种含有84个氨基酸的多肽。
Parathyroid hormone (1-34) (bovine) is a parathyroid hormone (PTH) receptor agonist. It increases calcium and inorganic phosphate levels in the serum of young rats. Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids.
| DOI | 名称 | |
|---|---|---|
| 10.1359/JBMR.0301226 | PTH differentially regulates expression of RANKL and OPG | 下载 |
| 10.1021/jf040457i | A gamma-glutamyl peptide isolated from onion (Allium cepa L.) by bioassay-guided fractionation inhibits resorption activity of osteoclasts | 下载 |
| 10.1111/j.1747-0285.2007.00615.x | SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity | 下载 |
| 10.1073/pnas.87.1.108 | Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system | 下载 |
| 10.1002/jbmr.324 | Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow | 下载 |
| 10.1159/000330079 | Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter | 下载 |
| 10.1016/j.actbio.2013.08.039 | Soluble silica inhibits osteoclast formation and bone resorption in vitro | 下载 |
| 10.1002/jbmr.2417 | A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse | 下载 |
| 10.1371/journal.pone.0120402 | The effect of bovine parathyroid hormone withdrawal on MC3T3-E1 cell proliferation and phosphorus metabolism | 下载 |
| 10.1016/0003-9861(87)90639-4 | Proton NMR studies of the biologically active 1-34 fragment of bovine parathyroid hormone: examination of a structural model | 下载 |
| 10.1016/0016-6480(86)90260-1 | Comparative study on the cardiac actions of bovine parathyroid hormone (1-34) | 下载 |
| 10.1016/0014-2999(84)90452-7 | Effects of synthetic parathyroid hormone on hemodynamics and regional blood flows | 下载 |
| 10.1210/jcem-56-6-1335 | Preparation of synthetic bovine parathyroid hormone fragment 1-34 for parenteral use in human studies | 下载 |
| 10.3181/00379727-168-41253 | Acute hypotensive action of parathyroid hormone-(1--34) fragments in hypertensive rats | 下载 |
| 10.1002/jcb.22059 | The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival | 下载 |
| 10.1007/s11010-010-0634-z | Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I | 下载 |
| 10.1002/jcb.23208 | Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone | 下载 |
| 10.3892/ijmm.2015.2423 | Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R | 下载 |
