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神经肽 S,即 SFRNGVGTGMKKTSFQRAKS,参与调节唤醒和恐惧反应。NPS 的侧脑室给药导致食物摄入量显着减少。
编号:137826
CAS号:412938-75-1
单字母:H2N-SFRNGVGSGVKKTSFRRAKQ-OH
神经肽 S,即 SFRNGVGTGMKKTSFQRAKS,参与调节唤醒和恐惧反应。NPS 的侧脑室给药导致食物摄入量显着减少。
Neuropeptide S, SFRNGVGTGMKKTSFQRAKS, is involved in the modulation of arousal and fear responses. Lateral ventricle administration of NPS caused a significant decrease in food intake.
神经肽S是一种在调节睡眠和压力中起主要作用的神经肽,是一种强效的内源性神经肽S受体(NSPR)激动剂(EC50=3.2 nM,用于诱导表达人类受体的HEK293细胞中的细胞内钙动员)。它在巩固期增强记忆,并与大脑中的去甲肾上腺素能系统相互作用。
Neuropeptide S, a neuropeptide that plays a major role in regulating sleep and stress, is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM for inducing intracellular calcium mobilization in HEK293 cells expressing the human receptor). It enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain.
DOI | 名称 | |
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10.1038/npp.2011.317 | Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons | 下载 |
10.3389/fnbeh.2014.00185 | Anti-aggressive effects of neuropeptide S independent of anxiolysis in male rats | 下载 |
10.3389/fnana.2015.00126 | Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons | 下载 |