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专注多肽 服务科研

编号:167444
CAS号:220384-25-8
单字母:H2N-RSCIDTIPKSRCTAFQCKHSM-Dap-YRLSFCRKTCGTC-OH
Kv1.3 blocker
22 位 D‑精氨酸取代向日葵海葵神经毒素在 22 位引入 D 型氨基酸取代,提高多肽结合亲和力与稳定性。该多肽来源于海葵毒液,是强效钾通道抑制剂。研究人员将其用于离子通道调控研究,并作为工具探究涉及离子通道功能异常的自身免疫疾病。
"(Dap22)-Stichodactyla helianthus Neurotoxin (ShK) incorporates a D-amino acid substitution at position 22, enhancing the peptides binding affinity and stability. The peptide is derived from sea anemone venom and is a potent inhibitor of potassium channels. Researchers apply it to study ion channel regulation and as a tool for investigating autoimmune disorders involving ion channel dysfunction."




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