| 编号: | 434450 |
| 中文名称: | S1P1 |
| 英文名: | S1P1 |
| 单字母: | H2N-VSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIK-OH |
| 三字母: | H2N N端氨基 -Val缬氨酸 -Ser丝氨酸 -Thr苏氨酸 -Ser丝氨酸 -Ile异亮氨酸 -Pro脯氨酸 -Glu谷氨酸 -Val缬氨酸 -Lys赖氨酸 -Ala丙氨酸 -Leu亮氨酸 -Arg精氨酸 -Ser丝氨酸 -Ser丝氨酸 -Val缬氨酸 -Ser丝氨酸 -Asp天冬氨酸 -Tyr酪氨酸 -Gly甘氨酸 -Asn天冬酰胺 -Tyr酪氨酸 -Asp天冬氨酸 -Ile异亮氨酸 -Ile异亮氨酸 -Val缬氨酸 -Arg精氨酸 -His组氨酸 -Tyr酪氨酸 -Asn天冬酰胺 -Tyr酪氨酸 -Thr苏氨酸 -Gly甘氨酸 -Lys赖氨酸 -Leu亮氨酸 -Asn天冬酰胺 -Ile异亮氨酸 -Gly甘氨酸 -Ala丙氨酸 -Glu谷氨酸 -Lys赖氨酸 -Asp天冬氨酸 -His组氨酸 -Gly甘氨酸 -Ile异亮氨酸 -Lys赖氨酸 -OHC端羧基 |
| 氨基酸个数: | 45 |
| 分子式: | C222H352N62O70 |
| 平均分子量: | 5009.54 |
| 精确分子量: | 5006.59 |
| 等电点(PI): | 10.71 |
| pH=7.0时的净电荷数: | 6.45 |
| 平均亲水性: | 0.0025 |
| 疏水性值: | -0.46 |
| 消光系数: | 5960 |
| 标签: | 细胞粘附肽(Cell Adhesion Peptides) |
Discovery
Synthetic cell adhesion peptides were first derived from laminin. The peptide PA22-2 (CSRARKQAASIKVAVSADR-NH2) derived from laminin was found to function as a cell adhesion molecule which was tested with mouse mast cells1.
Classification
Cell adhesion peptides for the most part are extracellular matrix proteins1.
Structural Characteristics
Numerous cell adhesion peptides have been synthesized to date. Some examples include: RU-1 (LNIVSVNGRHX), RX-1 (DNRIRLQAKXX), GD-1 (KATPMLKMRTSFHGCIK), GD-2 (KEGYKVRLDLNITLEFRTTSK), GD-3 (KNLEISRSTFDLLRNSYGVRK), GD-6 (KQNCLSSRASFRGCVRNLRLSR), HGD-6 (KQKCLRSQTSFRGCLRKLALIK), SGD-6 (CRNRGRCNSSLFQVRSRKLLSA), HSGD-6 (KQCLKSQRSFTRGLCRLKAKIL), AG-1 (KLLISRARKQÁASIK), F17 (LERKYENDQKYLEDKA) and KRGD (VEKRGDREEA). Peptides that are linear and cyclic in nature have been synthesized2.
Mode of action
Cell adhesion peptides can bind to the cell membrane and trigger adhesion of cells3.
Functions
Cell adhesion peptides have known to increase signaling via receptors3. They have been shown to decrease tumor metastasis and growth in experimental animals3. These peptides also induce Ca2+ signaling and modulate platelet activity3.
References
1. Thompson HL, Burbelo PD,Yamada Y,Kleinman HK and Metcalfe DD (1991). Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading, Immunology, 72, 144-149.
2. Gehlsen KR, Sriramarao P, Furcht LT and Skubitzt APN (1992). A Synthetic Peptide Derived from the Carboxy Terminus of the Laminin A Chain Represents a Binding Site for the a3ß1 Integrin, J Cell Biology,117 (2), 449-459.
3. Book: Proteins analysis and design, Angeletti RH, 222-226.
